iPTMnet Report for P31946 (YWHAB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31946 / 1433B_HUMAN
Protein Name 14-3-3 protein beta/alpha
Gene Name Name: YWHAB
Organism Homo sapiens (Human)

PRO ID PR:P31946
DAG View
PRO Name 14-3-3 protein beta/alpha (human)
Definition A 14-3-3 protein beta/alpha that is encoded in the genome of human.
Short Label hYWHAB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31946 (YWHAB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T2 Acetylation UniProt 25489052, 22814378
T2 Phosphorylation PhosphoSitePlus   UniProt 23186163
K5 Acetylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
Y21 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K51 Methylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S60 Phosphorylation Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9705322, 16024783
S66 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus   UniProt 19608861
K70 Ubiquitination PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus   UniProt 19608861
K117 Ubiquitination PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
S132 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor 10620507, 16024783
S136 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
S186 Phosphorylation P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15696159
C191 Methylation IEDB 31844290
K195 Ubiquitination PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus   UniProt 24275569
A241 Farnesylation IntAct 23622247
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 19413330
S60 Phosphorylation HPRD 9705322
S132 Phosphorylation Q05513 (PRKCZ) HPRD 10620507
T143 Phosphorylation Q05513 (PRKCZ) HPRD 10620507
S186 Phosphorylation HPRD 18510355, 7890696, 20058876
Site PTM Type PTM Enzyme Score Source PMID
K49 Acetylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025727 (hBCL2L11/iso:1/Phos:1) Interaction PR:P31946 (hYWHAB) PRO 16282323
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P31946 (hYWHAB) PRO 15057270


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K11 E11 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S47 F47 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S60 F60 Biomuta DOID:4159 / skin cancer [ cosmic ]
K77 Q77 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K117 R117 Biomuta DOID:363 / uterine cancer [ icgc ]
K124 E124 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y180 F180 Biomuta DOID:1324 / lung cancer [ cosmic ]
T207 M207 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T217 S217 Biomuta DOID:3571 / liver cancer [ cosmic ]
S232 W232 Biomuta DOID:2531 / hematologic cancer [ cosmic ]