iPTMnet Report for P31943 (HNRNPH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31943 / HNRH1_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein H
Gene Name Name: HNRNPH1
Synonyms:HNRPH,HNRPH1;
Organism Homo sapiens (Human)

PRO ID PR:P31943
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein H (human)
Definition A heterogeneous nuclear ribonucleoprotein H that is encoded in the genome of human.
Short Label hHNRNPH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31943 (HNRNPH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
M2 Acetylation UniProt 19413330, 22814378, 22223895
T5 Phosphorylation HPRD   PhosphoSitePlus 18491316
K14 Sumoylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S23 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 19690332
R29 Methylation PhosphoSitePlus
C34 S-Nitrosylation dbSNO 19483679
K35 Sumoylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
R44 Methylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   UniProt 23186163
S63 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18767875, 19664994, 18669648, 19690332, 20068231
K68 Sumoylation PhosphoSitePlus
K72 Sumoylation PhosphoSitePlus
R81 Methylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K98 Sumoylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T100 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15144186, 19415658, 20068231, ...19664995
S104 O-Glycosylation GlyGen 23301498, 30444036, 34019948, ...30397120, 24126823, 16732326, 34725712, 26853435, 33214551, 29351928, 35132862, 35083852, 32870666, 34931806, 32119511, 35289036, 28510447, 22121020, 33465208
S104 Phosphorylation P28482 (MAPK1) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19413330, 22028470, 18212344, ...18220336, 18767875, 18847512, 20058876, 19664995, 18452278, 19651622, 17322306, 18669648, 18707149, 19415658, 20068231, 17924679
T107 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17322306, 18212344, 19562805, ...18767875, 19664995, 19651622, 18669648, 19415658, 20068231
R114 Methylation PhosphoSitePlus
C122 S-Nitrosylation dbSNO 19483679
S123 Phosphorylation PhosphoSitePlus
S151 Phosphorylation HPRD   phospho.ELM 18669648
T152 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 30444036, 34019948, ...30397120, 24126823, 16732326, 34725712, 26853435, 33214551, 29351928, 35132862, 35083852, 32870666, 34931806, 32119511, 35289036, 28510447, 22121020, 33465208
S161 Phosphorylation PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y180 Phosphorylation HPRD   PhosphoSitePlus 20068231
K185 Acetylation PhosphoSitePlus
K185 Methylation PhosphoSitePlus
K185 Sumoylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S186 Phosphorylation HPRD   PhosphoSitePlus 20068231
S187 Phosphorylation HPRD   PhosphoSitePlus 20068231
T193 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
R199 Methylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
R206 Methylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
R212 Methylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
R224 Methylation PhosphoSitePlus
R230 Methylation PhosphoSitePlus
R232 Methylation PhosphoSitePlus
R233 Methylation PhosphoSitePlus   UniProt 24129315
Y236 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
Y249 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
R259 Methylation PhosphoSitePlus
R262 Methylation PhosphoSitePlus
Y266 Phosphorylation HPRD   PhosphoSitePlus 19901323
C267 S-Nitrosylation dbSNO 19483679, 2212679, 22126794, ...22178444, 20140087
S269 O-Glycosylation GlyGen 23301498, 30444036, 34019948, ...30397120, 24126823, 16732326, 34725712, 26853435, 33214551, 29351928, 35132862, 35083852, 32870666, 34931806, 32119511, 35289036, 28510447, 22121020, 33465208
S269 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
C290 Methylation IEDB 31844290
R294 Methylation PhosphoSitePlus
T301 O-Glycosylation GlyGen 23301498, 30444036, 34019948, ...30397120, 24126823, 16732326, 34725712, 26853435, 33214551, 29351928, 35132862, 35083852, 32870666, 34931806, 32119511, 35289036, 28510447, 22121020, 33465208
T301 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
S310 O-Glycosylation GlyGen 23301498, 30444036, 34019948, ...30397120, 24126823, 16732326, 34725712, 26853435, 33214551, 29351928, 35132862, 35083852, 32870666, 34931806, 32119511, 35289036, 28510447, 22121020, 33465208
S310 Phosphorylation HPRD   PhosphoSitePlus 17924679, 18452278
T328 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S363 O-Glycosylation GlyGen 23301498, 30444036, 34019948, ...30397120, 24126823, 16732326, 34725712, 26853435, 33214551, 29351928, 35132862, 35083852, 32870666, 34931806, 32119511, 35289036, 28510447, 22121020, 33465208
S368 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K14 T14 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S21 P21 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S23 L23 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R29 M29 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R29 S29 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K35 N35 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K87 M87 Biomuta DOID:3571 / liver cancer [ cosmic ]
S88 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S88 L88 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K98 N98 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C122 F122 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S161 L161 Biomuta DOID:4159 / skin cancer [ cosmic ]
K170 Q170 Biomuta DOID:363 / uterine cancer [ icgc ]
K185 R185 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T193 I193 Biomuta DOID:4159 / skin cancer [ cosmic ]
R199 Q199 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R199 L199 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R206 L206 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R206 P206 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R206 Q206 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R206 W206 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y210 C210 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R212 G212 Biomuta DOID:3571 / liver cancer [ cosmic ]
R212 K212 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
R217 I217 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R217 T217 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R232 S232 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y236 N236 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y266 H266 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y276 D276 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R294 L294 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T301 S301 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y306 D306 Biomuta DOID:3571 / liver cancer [ cosmic ]
S346 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S368 I368 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y372 N372 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y376 H376 Biomuta DOID:9256 / colorectal cancer [ cosmic ]