iPTMnet Report for P31629 (HIVEP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31629 / ZEP2_HUMAN
Protein Name Transcription factor HIVEP2
Gene Name Name: HIVEP2
Organism Homo sapiens (Human)

PRO ID PR:P31629
DAG View
PRO Name transcription factor HIVEP2 (human)
Definition A transcription factor HIVEP2 that is encoded in the genome of human.
Short Label hHIVEP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31629 (HIVEP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S163 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S166 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
T251 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S296 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S384 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S389 Phosphorylation PhosphoSitePlus
S392 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S402 Phosphorylation PhosphoSitePlus
S404 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S406 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
T416 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S420 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S420 Phosphorylation PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S433 Phosphorylation IEDB   PhosphoSitePlus 32387766
T441 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T442 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T443 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S444 O-Glycosylation GlyGen 30620550
K453 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
S500 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S511 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
K517 Ubiquitination PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S545 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T548 Phosphorylation PhosphoSitePlus
S549 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T552 Phosphorylation PhosphoSitePlus
S563 O-Glycosylation GlyGen 30620550
S565 Phosphorylation PhosphoSitePlus
K616 Methylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
K624 Methylation PhosphoSitePlus
K626 Methylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
Y638 Phosphorylation PhosphoSitePlus
Y645 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
S924 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T926 Phosphorylation PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
S968 Phosphorylation PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus
S1032 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
S1050 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1050 Phosphorylation PhosphoSitePlus
S1057 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1062 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 32938750, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1085 Phosphorylation PhosphoSitePlus
S1087 Phosphorylation PhosphoSitePlus
S1089 Phosphorylation PhosphoSitePlus
T1274 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T1278 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1283 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 32938750, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1286 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
K1291 Ubiquitination PhosphoSitePlus
K1296 Ubiquitination PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
S1320 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1325 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1328 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 32938750, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T1377 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T1380 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1443 Phosphorylation PhosphoSitePlus
S1446 Phosphorylation PhosphoSitePlus
S1447 Phosphorylation PhosphoSitePlus
T1454 Phosphorylation PhosphoSitePlus
K1455 Ubiquitination PhosphoSitePlus
S1488 Phosphorylation IEDB 32387766
S1579 Phosphorylation PhosphoSitePlus
S1586 Phosphorylation PhosphoSitePlus
K1666 Methylation PhosphoSitePlus
Y1705 Phosphorylation IEDB 28228285
K1717 Ubiquitination PhosphoSitePlus
K1725 Ubiquitination PhosphoSitePlus
K1731 Ubiquitination PhosphoSitePlus
K1741 Ubiquitination PhosphoSitePlus
K1745 Ubiquitination PhosphoSitePlus
K1752 Ubiquitination PhosphoSitePlus
K1768 Ubiquitination PhosphoSitePlus
Y1782 Phosphorylation PhosphoSitePlus
K1783 Ubiquitination PhosphoSitePlus
S1784 Phosphorylation PhosphoSitePlus
Y1788 Phosphorylation PhosphoSitePlus
K1798 Ubiquitination PhosphoSitePlus
T1820 Phosphorylation PhosphoSitePlus
T1822 Phosphorylation PhosphoSitePlus
T1936 Phosphorylation PhosphoSitePlus
S1937 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1945 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1961 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T1974 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S1977 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
T1981 Phosphorylation HPRD   PhosphoSitePlus 18491316
T1985 Phosphorylation HPRD   PhosphoSitePlus 18491316
S1987 Phosphorylation HPRD   PhosphoSitePlus 18491316
T1996 Phosphorylation HPRD   PhosphoSitePlus 18491316
Y1998 Phosphorylation HPRD   PhosphoSitePlus 18491316
S2034 Phosphorylation PhosphoSitePlus
S2035 Phosphorylation PhosphoSitePlus
S2059 Phosphorylation PhosphoSitePlus
S2071 Phosphorylation PhosphoSitePlus
S2077 Phosphorylation PhosphoSitePlus
S2083 Phosphorylation PhosphoSitePlus
K2092 Ubiquitination PhosphoSitePlus
S2112 Phosphorylation PhosphoSitePlus
S2118 Phosphorylation IEDB   PhosphoSitePlus   UniProt 23186163, 27869121, 11120772
S2130 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S2145 Phosphorylation IEDB 35494241
S2157 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...30379171, 29351928, 34019948, 35254053, 35132862, 31492838, 35289036, 30620550, 28657654
S2297 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2298 Phosphorylation PhosphoSitePlus
S2300 Phosphorylation PhosphoSitePlus
S2301 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2331 Acetylation PhosphoSitePlus
T2402 Phosphorylation PhosphoSitePlus
S2435 Phosphorylation PhosphoSitePlus
S2440 Phosphorylation PhosphoSitePlus
S2443 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 F71 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S169 N169 Biomuta DOID:4159 / skin cancer [ cosmic ]
S169 I169 Biomuta DOID:1324 / lung cancer [ cosmic ]
T212 N212 Biomuta DOID:363 / uterine cancer [ icgc ]
K358 T358 Biomuta DOID:4159 / skin cancer [ cosmic ]
K358 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K368 R368 Biomuta DOID:3571 / liver cancer [ cosmic ]
S384 L384 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S406 N406 Biomuta DOID:4159 / skin cancer [ cosmic ]
S545 P545 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S565 T565 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K616 N616 Biomuta DOID:1324 / lung cancer [ cosmic ]
S629 Y629 Biomuta DOID:363 / uterine cancer [ icgc ]
S702 R702 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S813 L813 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S955 I955 Biomuta DOID:3571 / liver cancer [ cosmic ]
S955 T955 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1085 F1085 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1291 N1291 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1296 T1296 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1320 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S1320 L1320 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S1325 F1325 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1325 Y1325 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1705 F1705 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1705 H1705 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1784 L1784 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1822 N1822 Biomuta DOID:363 / uterine cancer [ icgc ]
T1822 P1822 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1985 A1985 Biomuta DOID:363 / uterine cancer [ icgc ]
S2059 L2059 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2130 F2130 Biomuta DOID:1319 / brain cancer [ icgc ]
S2145 F2145 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2301 F2301 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2435 I2435 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]