iPTMnet Report for P31350 (RRM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31350 / RIR2_HUMAN
Protein Name Ribonucleoside-diphosphate reductase subunit M2
Gene Name Name: RRM2
Synonyms:RR2;
Organism Homo sapiens (Human)

PRO ID PR:P31350
DAG View
PRO Name ribonucleoside-diphosphate reductase subunit M2 (human)
Definition A ribonucleoside-diphosphate reductase subunit M2 that is encoded in the genome of human.
Short Label hRRM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31350 (RRM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T12 Phosphorylation PhosphoSitePlus
S20 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16964243, 18847512, 18234856, ...33936100, 18669648, 17693683, 30784271, 9990288
S20 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 9990288, 18234856
S20 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K23 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
T33 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33372599, 18669648, 22632967, ...26602815
T33 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 22632967
T33 Phosphorylation P24941 (CDK2) PhosphoSitePlus 22632967
S38 Phosphorylation PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
T56 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S150 Phosphorylation RLIMS-P 31324785
C160 Methylation IEDB 31844290
C202 Methylation IEDB 31844290
K204 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
R212 Methylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
C274 Methylation IEDB 31844290
K278 Ubiquitination PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
C317 Methylation IEDB 31844290
T318 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K364 Acetylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 19413330, 18767875, 20058876, ...19664995, 18669648, 9990288, 19415658, 17924679
S20 Phosphorylation P06493 (CDK1) HPRD 19413330, 18767875, 20058876, ...19664995, 18669648, 9990288, 19415658, 17924679
T33 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31350 (RRM2) S150 Q8IXJ6 (SIRT2) increased_association eFIP 31324785
Phosphorylation P31350 (RRM2) T33 P48637 (GSS) inhibited_association eFIP 33372599


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T318 A318 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]