iPTMnet Report for P31150 (GDI1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31150 / GDIA_HUMAN
Protein Name Rab GDP dissociation inhibitor alpha
Gene Name Name: GDI1
Synonyms:GDIL,OPHN2,RABGDIA,XAP4;
Organism Homo sapiens (Human)

PRO ID PR:P31150
DAG View
PRO Name Rab GDP dissociation inhibitor alpha (human)
Definition A Rab GDP dissociation inhibitor alpha that is encoded in the genome of human.
Short Label hGDI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31150 (GDI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
R35 Methylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
S43 Phosphorylation HPRD 20068231
S45 Phosphorylation HPRD 20068231
K54 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
R68 Methylation PhosphoSitePlus
R70 Methylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
R169 Methylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K210 Acetylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K221 Methylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
S222 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y224 Phosphorylation PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
Y229 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K264 Methylation PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
R290 Methylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
C317 S-Nitrosylation dbSNO 2212679, 22126794
Y333 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
T413 Phosphorylation HPRD   PhosphoSitePlus 18452278
K435 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S65 L65 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y111 C111 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y117 S117 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K142 T142 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R169 H169 Biomuta [ cosmic ]
R169 C169 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y226 F226 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K278 N278 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R290 S290 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K309 E309 Biomuta DOID:4159 / skin cancer [ cosmic ]
K309 R309 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y349 H349 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]