iPTMnet Report for P30740 (SERPINB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30740 / ILEU_HUMAN
Protein Name Leukocyte elastase inhibitor
Gene Name Name: SERPINB1
Synonyms:ELANH2,MNEI,PI2;
Organism Homo sapiens (Human)

PRO ID PR:P30740
DAG View
PRO Name leukocyte elastase inhibitor (human)
Definition A leukocyte elastase inhibitor that is encoded in the genome of human.
Short Label hSERPINB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30740 (SERPINB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 12665801
T62 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
K137 Acetylation PhosphoSitePlus   UniProt 19608861
K137 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus   UniProt 19608861
K177 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K203 Acetylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus   UniProt 23186163
K301 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y282 Phosphorylation HPRD 17924679
S286 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T62 M62 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K137 N137 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y282 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]