iPTMnet Report for P30411 (BDKRB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30411 / BKRB2_HUMAN
Protein Name B2 bradykinin receptor
Gene Name Name: BDKRB2
Synonyms:BKR2;
Organism Homo sapiens (Human)

PRO ID PR:P30411
DAG View
PRO Name B2 bradykinin receptor (human)
Definition A B2 bradykinin receptor that is encoded in the genome of human.
Short Label hBDKRB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30411 (BDKRB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 16226010
S178 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation phospho.ELM   PhosphoSitePlus 15161928
Y347 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 16226010
S358 Phosphorylation PhosphoSitePlus
S366 Phosphorylation P32298 (GRK4) , P35626 (GRK3) , P25098 (GRK2) , P43250 (GRK6) , P34947 (GRK5) phospho.ELM   PhosphoSitePlus   Signor 11517230
S373 Phosphorylation P35626 (GRK3) , P43250 (GRK6) , P17252 (PRKCA) , Q05655 (PRKCD) , P25098 (GRK2) , P32298 (GRK4) , P34947 (GRK5) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11517230
S375 Phosphorylation P34947 (GRK5) , P35626 (GRK3) , P32298 (GRK4) , P25098 (GRK2) , P43250 (GRK6) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11517230
K382 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y156 Phosphorylation HPRD 10085087
Y347 Phosphorylation HPRD 10085087
S358 Phosphorylation HPRD 10085087
S366 Phosphorylation P32298 (GRK4) , P34947 (GRK5) , P43250 (GRK6) , A0A0S2Z3I6 (ADRBK1) , L0R4T6 (ADRBK2) HPRD 11517230
T369 Phosphorylation HPRD 11517230
S373 Phosphorylation P32298 (GRK4) , Q05655 (PRKCD) , A0A0S2Z3I6 (ADRBK1) , P34947 (GRK5) , L0R4T6 (ADRBK2) , P43250 (GRK6) HPRD 11517230
S375 Phosphorylation P32298 (GRK4) , P34947 (GRK5) , P43250 (GRK6) , A0A0S2Z3I6 (ADRBK1) , L0R4T6 (ADRBK2) HPRD 11517230
Site PTM Type PTM Enzyme Score Source PMID
S346 Phosphorylation P43250 (GRK6) neXtProt 11517230
S348 Phosphorylation P43250 (GRK6) neXtProt 11517230


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 F17 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S348 F348 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S358 P358 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S375 F375 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K382 T382 Biomuta DOID:9256 / colorectal cancer [ icgc ]