iPTMnet Report for P30304 (CDC25A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30304 / MPIP1_HUMAN
Protein Name M-phase inducer phosphatase 1
Gene Name Name: CDC25A
Organism Homo sapiens (Human)

PRO ID PR:P30304
DAG View
PRO Name M-phase inducer phosphatase 1 (human)
Definition An M-phase inducer phosphatase 1 that is encoded in the genome of human.
Short Label hCDC25A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30304 (CDC25A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S18 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12411508
S40 Phosphorylation PhosphoSitePlus   RLIMS-P 28192398
Y59 Phosphorylation PhosphoSitePlus   RLIMS-P 27485204
S69 O-Glycosylation GlyGen 29485866, 30379171, 29237092
S76 Phosphorylation O14757 (CHEK1) , P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 20348946, 28680535, 18480045, ...12759351, 21252624, 29725502, 22179839, 20068082, 12110582, 14681206, 20639859, 18167338
S77 Phosphorylation PhosphoSitePlus
S79 Phosphorylation Q8NG66 (NEK11) , P48729 (CSNK1A1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14681206, 20348946, 19734889
T80 Phosphorylation Q9H4B4 (PLK3) PhosphoSitePlus   Signor 18167338
S82 Phosphorylation P48729 (CSNK1A1) , Q8NG66 (NEK11) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20348946, 28680535, 29725502, ...20462953, 19734889, 14681206, 20090422
S88 Phosphorylation Q8NG66 (NEK11) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14603323, 20090422, 19734889, ...28192398
S107 Phosphorylation PhosphoSitePlus   UniProt 23186163
K111 Ubiquitination PhosphoSitePlus
S116 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12411508
K120 Ubiquitination PhosphoSitePlus
S124 Phosphorylation Q683Z8 (CHK2) , O96017 (CHEK2) , O14757 (CHEK1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12759351, 11298456, 21761201, ...12676583, 14681206, 12399544, 20068082
S126 Phosphorylation PhosphoSitePlus
K150 Acetylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S178 Phosphorylation Q683Z8 (CHK2) , O14757 (CHEK1) , O96017 (CHEK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20068082, 12759351, 12676583, ...14559997
S185 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S263 Phosphorylation P24941 (CDK2) Signor 17110335
R278 Methylation PhosphoSitePlus
S279 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) , Q683Z8 (CHK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 20068082, 12676583
S283 Phosphorylation PhosphoSitePlus   RLIMS-P 27580187
R290 Methylation PhosphoSitePlus
S293 Phosphorylation O14757 (CHEK1) , O96017 (CHEK2) , Q15418 (RPS6KA1) , Q683Z8 (CHK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 23708659, 20068082, 12676583
S295 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus   Signor 23708659
K300 Ubiquitination PhosphoSitePlus
S317 Phosphorylation RLIMS-P 26714930
S320 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus   UniProt 23186163
K343 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
C481 Methylation IEDB 31844290
Y486 Phosphorylation PhosphoSitePlus   RLIMS-P 27485204
T507 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20068082, 20639859, 14559997
S513 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   UniProt 21376736
Y518 Phosphorylation RLIMS-P 27485204
S519 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   UniProt 21376736
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation P06493 (CDK1) HPRD 12411508
S76 Phosphorylation HPRD 12110582, 12963847
S116 Phosphorylation P06493 (CDK1) , P11309 (PIM1) HPRD 19413330, 12411508
S124 Phosphorylation O14757 (CHEK1) HPRD 12963847, 12399544
S178 Phosphorylation O14757 (CHEK1) , O96017 (CHEK2) HPRD 12676583
S279 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) HPRD 12676583
S293 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) HPRD 12676583
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation P06493 (CDK1) HPRD 12411508
S76 Phosphorylation HPRD 12110582, 12963847
S116 Phosphorylation P06493 (CDK1) HPRD 19413330, 12411508
S124 Phosphorylation O14757 (CHEK1) HPRD 12963847, 12399544
S239 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) HPRD 12676583
S253 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) HPRD 12676583


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046659 (hCDC25A/Phos:1) pS124 PRO
PR:000046660 (hCDC25A/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14757 (CHEK1) S296 P30304 (CDC25A) unknown eFIP 20639859
Phosphorylation P30304 (CDC25A) T507 O14757 (CHEK1) unknown eFIP 14559997
Phosphorylation P30304 (CDC25A) Y59 P14618 (PKM) unknown eFIP 27485204
Phosphorylation Q08050 (FOXM1) T600 P30304 (CDC25A) increased_association eFIP 23240008


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S69 T69 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S69 G69 Biomuta DOID:1324 / lung cancer [ cosmic ]
S88 F88 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S185 F185 Biomuta DOID:4159 / skin cancer [ cosmic ]
S253 N253 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R278 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S293 N293 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S317 F317 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S320 Y320 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S321 F321 Biomuta DOID:4159 / skin cancer [ cosmic ]
S367 C367 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S367 F367 Biomuta DOID:1612 / breast cancer [ cosmic ]
S367 P367 Biomuta DOID:1612 / breast cancer [ cosmic ]
K372 R372 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y486 D486 Biomuta DOID:4159 / skin cancer [ cosmic ]