iPTMnet Report for P30153 (PPP2R1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30153 / 2AAA_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Gene Name Name: PPP2R1A
Organism Homo sapiens (Human)

PRO ID PR:P30153
DAG View
PRO Name serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (human)
Definition A serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform that is encoded in the genome of human.
Short Label hPPP2R1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30153 (PPP2R1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
S9 Phosphorylation HPRD   PhosphoSitePlus 18491316
K34 Ubiquitination PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
R134 Methylation PhosphoSitePlus
C154 Methylation IEDB 31844290
K163 Ubiquitination PhosphoSitePlus
R167 Methylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K266 Acetylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K280 Acetylation PhosphoSitePlus   UniProt 19608861
K280 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
C294 Methylation IEDB 31844290
K305 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
C310 Methylation IEDB 31844290
C317 Methylation IEDB 31844290
C329 Methylation IEDB 31844290
S335 Phosphorylation HPRD   PhosphoSitePlus 20068231
K342 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
C390 S-Nitrosylation dbSNO 19483679
K416 Ubiquitination PhosphoSitePlus
K442 Sumoylation PhosphoSitePlus
C447 Methylation IEDB 31844290
K467 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
Y495 Phosphorylation PhosphoSitePlus
C512 Methylation IEDB 31844290
K519 Ubiquitination PhosphoSitePlus
R527 Methylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
T555 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 26853435, 29351928, 23576270, 34019948, 32119511
K561 Acetylation PhosphoSitePlus
K561 Sumoylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q5FBB7 (hSGO1) Interaction PR:P30153 (hPPP2R1A) PRO 16580887


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:363 / uterine cancer [ icgc ]
S36 F36 Biomuta DOID:4159 / skin cancer [ cosmic ]
S120 L120 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
R134 P134 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R134 W134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R167 Q167 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
R167 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K202 E202 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K255 N255 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K266 Q266 Biomuta DOID:1612 / breast cancer [ cosmic ]
K266 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K272 Q272 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
C294 R294 Biomuta DOID:1612 / breast cancer [ cosmic ]
C317 F317 Biomuta DOID:4159 / skin cancer [ cosmic ]
C329 F329 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S335 F335 Biomuta [ cosmic ]
K342 T342 Biomuta DOID:1324 / lung cancer [ cosmic ]
C512 Y512 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R527 C527 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R527 H527 Biomuta [ cosmic ]
K546 M546 Biomuta DOID:1612 / breast cancer [ cosmic ]
K546 T546 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S554 I554 Biomuta DOID:363 / uterine cancer [ icgc ]
S554 N554 Biomuta DOID:4159 / skin cancer [ cosmic ]