iPTMnet Report for P29350 (PTPN6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29350 / PTN6_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 6
Gene Name Name: PTPN6
Synonyms:HCP,PTP1C;
Organism Homo sapiens (Human)

PRO ID PR:P29350
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 6 (human)
Definition A tyrosine-protein phosphatase non-receptor type 6 that is encoded in the genome of human.
Short Label hPTPN6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29350 (PTPN6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S26 Phosphorylation IEDB   PhosphoSitePlus 35494241
K34 Ubiquitination PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus   UniProt 19690332
K97 Ubiquitination PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S151 O-Glycosylation GlyGen 30379171, 29351928
K155 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
Y208 Phosphorylation RLIMS-P 18617527
Y213 Phosphorylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S250 O-Glycosylation GlyGen 30379171, 29351928
S250 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
R286 Methylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
T350 O-Glycosylation GlyGen 30379171, 29351928
K360 Ubiquitination PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
C453 S-Nitrosylation dbSNO 15684422, 22178444
K486 Ubiquitination PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
Y536 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 23938089, 18377662, 14699166, ...24405902, 8692915, 7512963, 28250424, 18083107, 32792945, 17575265, 14757045, 17675340, 33370418, 12468540, 8114715, 8696915
Y536 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 8692915
Y536 Phosphorylation P00519 (ABL1) neXtProt   Signor 8692915, 8696915
Y536 Phosphorylation P06213 (INSR) neXtProt   PhosphoSitePlus   Signor 7512963
Y536 Phosphorylation P06239 (LCK) phospho.ELM   PhosphoSitePlus 8114715
Y536 Phosphorylation P07948 (LYN) PhosphoSitePlus 17675340
Y536 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 14699166
T540 Phosphorylation PhosphoSitePlus
Y541 Phosphorylation IntAct   PhosphoSitePlus 8114715
K546 Ubiquitination PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
T555 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
Y564 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10488096, 8696915, 14699166, ...8692915, 16649996, 28250424, 18083107, 32792945, 10574931, 14757045, 33370418, 25535246, 12468540, 8114715
Y564 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 8692915
Y564 Phosphorylation P00519 (ABL1) neXtProt   Signor 8692915, 8696915
Y564 Phosphorylation P06239 (LCK) phospho.ELM   PhosphoSitePlus   Signor 16649996, 10488096, 8114715
Y564 Phosphorylation P07948 (LYN) Signor 10574931
Y564 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 14699166
K570 Ubiquitination PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
S591 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18377662, 24405902, 28619847, ...21262353, 20351292, 15269224, 23938089, 32792945, 17575265, 18617527, 24947019, 23720348
S591 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 15269224
S591 Phosphorylation P24941 (CDK2) neXtProt 21262353, 18617527
Site PTM Type PTM Enzyme Score Source PMID
Y61 Phosphorylation HPRD 15592455
Y64 Phosphorylation HPRD 15592455
Y536 Phosphorylation HPRD 7512963, 16497976
Y536 Phosphorylation P00519 (ABL1) HPRD 7512963, 16497976
Y536 Phosphorylation P06213 (INSR) HPRD 7512963, 16497976
Y536 Phosphorylation P06239 (LCK) HPRD 7512963, 16497976
Y541 Phosphorylation HPRD 16497976
S557 Phosphorylation HPRD 20166139
Y564 Phosphorylation HPRD 10574931, 8692915, 10488096, ...8114715, 12468540
Y564 Phosphorylation P00519 (ABL1) HPRD 10574931, 8692915, 10488096, ...8114715, 12468540
Y564 Phosphorylation P06239 (LCK) HPRD 8114715
Y564 Phosphorylation P07948 (LYN) HPRD 10574931, 8692915, 10488096, ...8114715, 12468540
S591 Phosphorylation HPRD 15269224
S591 Phosphorylation P17252 (PRKCA) HPRD 15269224
Site PTM Type PTM Enzyme Score Source PMID
Y63 Phosphorylation HPRD 15592455
Y66 Phosphorylation HPRD 15592455
Y538 Phosphorylation HPRD 8114715, 16497976
Y538 Phosphorylation P06213 (INSR) HPRD 8114715, 16497976
Y538 Phosphorylation P06239 (LCK) HPRD 8114715, 16497976
Y543 Phosphorylation HPRD 16497976
S559 Phosphorylation HPRD 20166139
Y566 Phosphorylation HPRD 8114715
Y566 Phosphorylation P06239 (LCK) HPRD 8114715
Site PTM Type PTM Enzyme Score Source PMID
Y61 Phosphorylation HPRD 15592455
Y64 Phosphorylation HPRD 15592455
Y536 Phosphorylation HPRD 18083107, 16497976
Y541 Phosphorylation HPRD 16497976
S563 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06239 (LCK) S59 P29350 (PTPN6) inhibited_association eFIP 29187853


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 N10 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S26 N26 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S26 R26 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S26 T26 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y98 C98 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S151 N151 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S151 G151 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K155 N155 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y176 N176 Biomuta DOID:1324 / lung cancer [ cosmic ]
T188 M188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K195 M195 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y208 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K253 M253 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K253 R253 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R286 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
R286 L286 Biomuta DOID:3571 / liver cancer [ cosmic ]
T350 I350 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S378 F378 Biomuta DOID:4159 / skin cancer [ cosmic ]
C453 F453 Biomuta [ cosmic ]
S496 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S528 P528 Biomuta DOID:263 / kidney cancer [ cosmic ]
S528 L528 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S553 P553 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S556 L556 Biomuta DOID:363 / uterine cancer [ icgc ]
K560 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S591 F591 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]