Protein Information

Cytoscape View


UniProt AC / UniProt ID P28799 / GRN_HUMAN
Protein Name Progranulin precursor
Gene Name Name: GRN
Organism Homo sapiens (Human)

PRO ID PR:P28799
DAG View
PRO Name progranulin (human)
Definition A progranulin that is encoded in the genome of human.
Short Label hGRN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28799 (GRN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S81 Phosphorylation PhosphoSitePlus   RLIMS-P 26005049
S81 Phosphorylation P05771 (PRKCB) PhosphoSitePlus 26005049
N118 N-Glycosylation GlyGen   UniProt 20188224
C178 Methylation IEDB 31844290
T180 Phosphorylation PhosphoSitePlus
T182 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T182 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
N236 N-Glycosylation GlyGen 23090970, 24190977
C253 Methylation IEDB 31844290
N265 N-Glycosylation GlyGen   UniProt 23090970, 20188224, 19159218, ...24190977
K273 Ubiquitination PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
C335 Methylation IEDB 31844290
N368 N-Glycosylation GlyGen   UniProt 20188224
S435 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
N530 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 24190977, ...20188224, 30237853
T532 O-Glycosylation GlyGen 33214551, 30237853, 30397120, ...34019948, 36240223, 22661428
N537 N-Glycosylation GlyGen 24190977
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 20068231
T11 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P28799 (GRN) S81 P28799 (GRN) unknown eFIP 26005049


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S205 L205 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S435 F435 Biomuta DOID:4159 / skin cancer [ cosmic ]
N530 S530 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
N530 I530 Biomuta DOID:1725 / peritoneum cancer [ cosmic ]
N530 K530 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]