iPTMnet Report for P27694 (RPA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P27694 / RFA1_HUMAN
Protein Name Replication protein A 70 kDa DNA-binding subunit
Gene Name Name: RPA1
Synonyms:REPA1,RPA70;
Organism Homo sapiens (Human)

PRO ID PR:P27694
DAG View
PRO Name replication protein A 70 kDa DNA-binding subunit (human)
Definition A replication protein A 70 kDa DNA-binding subunit that is encoded in the genome of human.
Short Label hRPA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27694 (RPA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895
S6 Phosphorylation HPRD   PhosphoSitePlus 20068231
K22 Ubiquitination PhosphoSitePlus   UniProt 26474068
T35 Phosphorylation HPRD   PhosphoSitePlus 20068231
S38 Phosphorylation PhosphoSitePlus
T60 Phosphorylation RLIMS-P 33784377
K88 Ubiquitination PhosphoSitePlus   UniProt 26474068
K111 Sumoylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
S135 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 33704464, 20068231
S149 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 34725712, 29351928, 34019948, 20305658, 32119511, 28510447
K157 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus   UniProt 19608861
K163 Methylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus   UniProt 26474068
T164 Phosphorylation HPRD   PhosphoSitePlus 18212344
K167 Acetylation PhosphoSitePlus   UniProt 19608861
K167 Methylation PhosphoSitePlus
K167 Sumoylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus   UniProt 26474068
S174 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
T180 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 33704464, 17525332, 18077418, ...20068231
S182 Phosphorylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus   UniProt 26474068
T191 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 20068231
S195 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
C200 Methylation IEDB 31844290
S207 Phosphorylation PhosphoSitePlus
R210 Methylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus   UniProt 26474068
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus   UniProt 26474068
K253 Acetylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus   UniProt 19608861
K259 Ubiquitination UniProt 26474068
K263 Ubiquitination PhosphoSitePlus
K267 Acetylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus   UniProt 26474068
C289 Methylation IEDB 31844290
S312 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus   UniProt 26474068
K367 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
S384 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S392 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus   UniProt 26474068
K431 Ubiquitination PhosphoSitePlus   UniProt 26474068
S432 Phosphorylation PhosphoSitePlus
K443 Methylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K449 Sumoylation PRO   PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus   UniProt 26474068
Y461 Phosphorylation PhosphoSitePlus
S463 Phosphorylation HPRD 20068231
S464 Phosphorylation HPRD 20068231
T467 Phosphorylation HPRD 20068231
Y470 Phosphorylation HPRD   PhosphoSitePlus 20068231
K473 Ubiquitination PhosphoSitePlus
Y478 Phosphorylation PhosphoSitePlus
T483 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K489 Acetylation PhosphoSitePlus
K489 Sumoylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K502 Acetylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus   UniProt 26474068
K577 Acetylation PhosphoSitePlus
K577 Sumoylation PRO   PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Y581 Phosphorylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
T590 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 34725712, 29351928, 34019948, 20305658, 32119511, 28510447
T590 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 33704464, 20068231
K595 Sumoylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
Y599 Phosphorylation HPRD   PhosphoSitePlus 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049063 (hRPA1/InitMet-/Sumo:1) suK449,suK577 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S15 P27694 (RPA1) inhibited_association eFIP 22288499


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S38 I38 Biomuta DOID:1324 / lung cancer [ cosmic ]
K88 T88 Biomuta DOID:1324 / lung cancer [ cosmic ]
S149 L149 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K157 N157 Biomuta DOID:1324 / lung cancer [ cosmic ]
R210 H210 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K220 M220 Biomuta DOID:3571 / liver cancer [ cosmic ]
S312 W312 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
S464 Y464 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S464 F464 Biomuta DOID:4159 / skin cancer [ cosmic ]
T467 R467 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]