iPTMnet Report for P25788 (PSMA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P25788 / PSA3_HUMAN
Protein Name Proteasome subunit alpha type-3
Gene Name Name: PSMA3
Synonyms:HC8,PSC8;
Organism Homo sapiens (Human)

PRO ID PR:P25788
DAG View
PRO Name proteasome subunit alpha type-3 (human)
Definition A proteasome subunit alpha type-3 that is encoded in the genome of human.
Short Label hPSMA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25788 (PSMA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895, ...12376572
Y8 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K57 Acetylation PhosphoSitePlus   UniProt 19608861
K57 Ubiquitination PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
C134 Methylation IEDB 31844290
S155 Phosphorylation IEDB 32387766
Y161 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K206 Acetylation PhosphoSitePlus   UniProt 19608861
K206 Ubiquitination PhosphoSitePlus
K230 Acetylation PhosphoSitePlus   UniProt 19608861
K230 Ubiquitination PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 8619999, 23186163, 17287340, ...17323924
K245 Ubiquitination PhosphoSitePlus
S250 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 8619999, 21406692, 23186163, ...16964243, 15302935, 17323924, 18318008, 19367720, 18669648, 12376572, 24275569, 17287340, 17487921, 19690332, 20068231, 17081983
Site PTM Type PTM Enzyme Score Source PMID
Y8 Phosphorylation HPRD 18491316
S16 Phosphorylation HPRD 20068231
Y161 Phosphorylation HPRD 15592455
S243 Phosphorylation P68400 (CSNK2A1) HPRD 19651622, 18767875, 19415658, ...20068231, 8619999
S250 Phosphorylation HPRD 19413330, 17322306, 18491316, ...17287340, 16964243, 18767875, 19664994, 19007248, 18452278, 19651622, 18669648, 20187088, 20166139, 19415658, 20068231, 18212344
Site PTM Type PTM Enzyme Score Source PMID
Y8 Phosphorylation HPRD 18491316
S16 Phosphorylation HPRD 20068231
Y154 Phosphorylation HPRD 15592455
S236 Phosphorylation HPRD 19651622, 18767875, 19415658, ...20068231, 8619999
S243 Phosphorylation HPRD 19413330, 17322306, 18491316, ...17287340, 16964243, 18767875, 19664994, 19007248, 18452278, 19651622, 18669648, 20187088, 20166139, 19415658, 20068231, 18212344


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K29 N29 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
K29 M29 Biomuta DOID:1324 / lung cancer [ cosmic ]
K65 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y105 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y154 F154 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y161 F161 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K192 E192 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S243 P243 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S250 P250 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]