iPTMnet Report for P25116 (F2R)
Protein Information
UniProt AC / UniProt ID | P25116 / PAR1_HUMAN |
Protein Name | Proteinase-activated receptor 1 precursor |
Gene Name | Name: F2R Synonyms:CF2R,PAR1,TR; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P25116 |
PRO Name | proteinase-activated receptor 1 (human) |
Definition | A proteinase-activated receptor 1 that is encoded in the genome of human. |
Short Label | hF2R |
Category | organism-gene |
P25116 (F2R) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
N35 | N-Glycosylation | score3 | GlyGen | 21550978, 24190977 | ||
K51 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y52 | Phosphorylation | score1 | PhosphoSitePlus | |||
N62 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
N75 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
N250 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
N259 | N-Glycosylation | score2 | GlyGen | 21550978 | ||
S306 | Phosphorylation | score1 | PhosphoSitePlus | |||
S375 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
S376 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
Y383 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 15023990 | ||
S384 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
S391 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
S392 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
S395 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
S396 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
Y397 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
S399 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
S400 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
S406 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
K407 | Ubiquitination | score1 | PhosphoSitePlus | |||
T410 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
S412 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 8955127 | ||
S413 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 | ||
S418 | Phosphorylation | score4 | HPRD phospho.ELM PhosphoSitePlus UniProt | 8955127, 23186163 | ||
Y420 | Phosphorylation | score1 | PhosphoSitePlus | |||
K421 | Ubiquitination | score1 | PhosphoSitePlus | |||
K422 | Ubiquitination | score1 | PhosphoSitePlus | |||
T425 | Phosphorylation | score3 | HPRD phospho.ELM | 8955127 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K51 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
Y52 | H52 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
N62 | D62 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S306 | I306 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S306 | R306 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S375 | F375 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic ] | |
S376 | F376 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
S392 | F392 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S399 | N399 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S413 | I413 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S413 | G413 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
S418 | N418 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y420 | H420 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
T425 | I425 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |