iPTMnet Report for P23381 (WARS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23381 / SYWC_HUMAN
Protein Name Tryptophan--tRNA ligase, cytoplasmic
Gene Name Name: WARS1
Synonyms:IFI53,WARS,WRS;
Organism Homo sapiens (Human)

PRO ID PR:P23381
DAG View
PRO Name tryptophan--tRNA ligase, cytoplasmic (human)
Definition A tryptophan--tRNA ligase, cytoplasmic that is encoded in the genome of human.
Short Label hWARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23381 (WARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K204 Acetylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
T207 Phosphorylation IEDB 32387766, 32157095
K220 Ubiquitination PhosphoSitePlus
C225 Methylation IEDB 31844290
K253 Ubiquitination PhosphoSitePlus
K256 Acetylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
C309 Methylation IEDB 31844290
Y316 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus   UniProt 23186163
S353 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K374 Acetylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
R381 Methylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
K431 Acetylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K465 Acetylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
S467 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16083285
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 20068231
S139 Phosphorylation HPRD 20068231
T259 Phosphorylation HPRD 20068231
S467 Phosphorylation HPRD 18669648, 16083285, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S98 Phosphorylation HPRD 20068231
T218 Phosphorylation HPRD 20068231
S426 Phosphorylation HPRD 18669648, 16083285, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K114 R114 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K204 Q204 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T218 A218 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T259 A259 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S353 C353 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S353 I353 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K432 E432 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T453 A453 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]