iPTMnet Report for P23284 (PPIB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23284 / PPIB_HUMAN
Protein Name Peptidyl-prolyl cis-trans isomerase B precursor
Gene Name Name: PPIB
Synonyms:CYPB;
Organism Homo sapiens (Human)

PRO ID PR:P23284
DAG View
PRO Name peptidyl-prolyl cis-trans isomerase B (human)
Definition A eukaryotic peptidyl-prolyl cis-trans isomerase B that is encoded in the genome of human.
Short Label hPPIB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23284 (PPIB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y47 Phosphorylation PhosphoSitePlus
R51 Methylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
R109 Methylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
K129 Methylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
S139 O-Glycosylation GlyGen 30444036, 36580660, 34725712, ...33214551, 34019948, 35083852, 32870666, 20305658, 32119511
S139 Phosphorylation HPRD   PhosphoSitePlus 20068231
K145 Acetylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
N148 N-Glycosylation GlyGen 23090970, 32125861, 24190977
S150 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K165 Acetylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
C202 Methylation IEDB 31844290
C202 S-Nitrosylation dbSNO 16648260, 22178444
K209 Acetylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K215 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T72 K72 Biomuta DOID:3571 / liver cancer [ cosmic ]
K84 E84 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y88 C88 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y88 H88 Biomuta DOID:1612 / breast cancer [ cosmic ]
R122 H122 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y133 C133 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T147 S147 Biomuta DOID:1324 / lung cancer [ cosmic ]
S150 F150 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S150 T150 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
C202 Y202 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]