iPTMnet Report for P23193 (TCEA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23193 / TCEA1_HUMAN
Protein Name Transcription elongation factor A protein 1
Gene Name Name: TCEA1
Synonyms:GTF2S,TFIIS;
Organism Homo sapiens (Human)

PRO ID PR:P23193
DAG View
PRO Name transcription elongation factor A protein 1 (human)
Definition A transcription elongation factor A protein 1 that is encoded in the genome of human.
Short Label hTCEA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23193 (TCEA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
K19 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus   UniProt 23186163
T58 Phosphorylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S81 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
T82 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
S97 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17525332, 21406692
S100 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 15302935, 17525332, 18669648, 24275569, 17287340, 20068231
T108 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S110 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S114 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S129 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K242 Methylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
C263 Methylation IEDB 31844290
C263 S-Nitrosylation dbSNO 26338901
K265 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
C271 S-Nitrosylation dbSNO 26338901
C291 S-Nitrosylation dbSNO 26338901
C294 S-Nitrosylation dbSNO 26338901
C301 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S81 Phosphorylation HPRD 17287340
T96 Phosphorylation HPRD 19651622, 20166139, 19415658, ...20068231, 19664995
S97 Phosphorylation HPRD 19413330, 17525332, 19664995, ...19651622, 18669648, 20166139, 20068231
S100 Phosphorylation HPRD 19413330, 17322306, 17287340, ...18212344, 18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231
T108 Phosphorylation HPRD 17287340
S109 Phosphorylation HPRD 17081983
S110 Phosphorylation HPRD 17287340
Y126 Phosphorylation HPRD 17287340
Site PTM Type PTM Enzyme Score Source PMID
K18 Acetylation PhosphoSitePlus
S22 Phosphorylation HPRD   PhosphoSitePlus 17287340
S28 Phosphorylation HPRD   PhosphoSitePlus 17287340
S47 Phosphorylation HPRD   PhosphoSitePlus 17287340
S60 Phosphorylation HPRD 17287340
T75 Phosphorylation HPRD 19651622, 20166139, 19415658, ...20068231, 19664995
S76 Phosphorylation HPRD 19413330, 17525332, 19664995, ...19651622, 18669648, 20166139, 20068231
S79 Phosphorylation HPRD 19413330, 17322306, 17287340, ...18212344, 18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231
T87 Phosphorylation HPRD 17287340
S88 Phosphorylation HPRD 17081983
S89 Phosphorylation HPRD 17287340
Y105 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 F22 Biomuta DOID:4159 / skin cancer [ cosmic ]
S57 N57 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K75 Q75 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T75 I75 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T96 I96 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S135 R135 Biomuta DOID:363 / uterine cancer [ icgc ]
S230 R230 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K242 E242 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
C263 Y263 Biomuta DOID:1319 / brain cancer [ icgc ]
C263 R263 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K265 I265 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C294 Y294 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]