iPTMnet Report for P23025 (XPA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23025 / XPA_HUMAN
Protein Name DNA repair protein complementing XP-A cells
Gene Name Name: XPA
Synonyms:XPAC;
Organism Homo sapiens (Human)

PRO ID PR:P23025
DAG View
PRO Name DNA repair protein complementing XP-A cells (human)
Definition A DNA repair protein complementing XP-A cells that is encoded in the genome of human.
Short Label hXPA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23025 (XPA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
Y48 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Sumoylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K86 Sumoylation PhosphoSitePlus
K141 Sumoylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K145 Sumoylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S173 Phosphorylation P78527 (PRKDC) , Q13535 (ATR) , Q13315 (ATM) HPRD   neXtProt   PhosphoSitePlus   Signor 16540648
S196 Phosphorylation P78527 (PRKDC) , Q13315 (ATM) , Q13535 (ATR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16540648, 17525332, 23186163, ...30327428, 35216341, 31779191, 23178497, 19586908
K204 Ubiquitination PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
C264 Methylation IEDB 31844290


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13535 (ATR) S435 P23025 (XPA) inhibited_association eFIP 24950377
Phosphorylation Q13535 (ATR) S435 P23025 (XPA) increased_association eFIP 28916831


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K86 N86 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S173 L173 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K215 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
T239 M239 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]