iPTMnet Report for P22612 (PRKACG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22612 / KAPCG_HUMAN
Protein Name cAMP-dependent protein kinase catalytic subunit gamma
Gene Name Name: PRKACG
Organism Homo sapiens (Human)

PRO ID PR:P22612
DAG View
PRO Name cAMP-dependent protein kinase catalytic subunit gamma (human)
Definition A cAMP-dependent protein kinase catalytic subunit gamma that is encoded in the genome of human.
Short Label hPRKACG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22612 (PRKACG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y118 Phosphorylation PhosphoSitePlus
Y123 Phosphorylation PhosphoSitePlus
R132 Methylation PhosphoSitePlus
T196 Phosphorylation HPRD   PhosphoSitePlus 18491316
T198 Phosphorylation HPRD   PhosphoSitePlus 18452278
T202 Phosphorylation PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus


P22612 (PRKACG) as PTM Enzyme



Substrate Site Score Source PMID
P29474 (NOS3) S1177 Signor 11729179
Q13185 (CBX3) S93 neXtProt 16531993
Q14896 (MYBPC3) S275 Signor 20151718
Q14896 (MYBPC3) S284 Signor 20151718
Q14896 (MYBPC3) S304 Signor 20151718
Q14896 (MYBPC3) S311 Signor 20151718
Q6PIY7 (TENT2) S116 Signor 31057087
Q92934 (BAD) S75 Signor 10230396, 10949026
Q92934 (BAD) S99 Signor 10949026
Q92934 (BAD) S118 Signor 10230396, 10949026


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y123 C123 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R132 H132 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
R132 G132 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T196 I196 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y205 D205 Biomuta DOID:1324 / lung cancer [ cosmic ]