iPTMnet Report for P22460 (KCNA5)
Protein Information
UniProt AC / UniProt ID | P22460 / KCNA5_HUMAN |
Protein Name | Potassium voltage-gated channel subfamily A member 5 |
Gene Name | Name: KCNA5 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P22460 |
PRO Name | potassium voltage-gated channel subfamily A member 5 (human) |
Definition | A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human. |
Short Label | hKCNA5 |
Category | organism-gene |
P22460 (KCNA5) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T15 | Phosphorylation | P17252 (PRKCA) | score3 | PhosphoSitePlus RLIMS-P | 16466689 | |
S62 | Phosphorylation | score1 | PhosphoSitePlus | |||
S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y203 | Phosphorylation | score1 | PhosphoSitePlus | |||
K221 | Sumoylation | score1 | PhosphoSitePlus | |||
C331 | S-Nitrosylation | score2 | dbSNO | 16876149, 22178444 | ||
C346 | S-Nitrosylation | score2 | dbSNO | 16876149, 22178444 | ||
S414 | Phosphorylation | score1 | PhosphoSitePlus | |||
S498 | Phosphorylation | score1 | PhosphoSitePlus | |||
K536 | Sumoylation | score1 | PhosphoSitePlus | |||
S557 | Phosphorylation | score1 | PhosphoSitePlus | |||
S559 | Phosphorylation | score1 | PhosphoSitePlus | |||
S575 | Phosphorylation | score1 | PhosphoSitePlus | |||
S592 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T15 | I15 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S192 | F192 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
C331 | Y331 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
C346 | S346 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S414 | Y414 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S414 | P414 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:2174 / ocular cancer [ cosmic ] | |
S498 | L498 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] |