iPTMnet Report for P20936 (RASA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P20936 / RASA1_HUMAN
Protein Name Ras GTPase-activating protein 1
Gene Name Name: RASA1
Synonyms:GAP,RASA;
Organism Homo sapiens (Human)

PRO ID PR:P20936
DAG View
PRO Name Ras GTPase-activating protein 1 (human)
Definition A Ras GTPase-activating protein 1 that is encoded in the genome of human.
Short Label hRASA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20936 (RASA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
Y164 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 1850098, 8828816
T462 Phosphorylation PhosphoSitePlus
Y472 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
Y615 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107
S754 Phosphorylation PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y952 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y460 Phosphorylation P00533 (EGFR) , P06239 (LCK) HPRD 1850098
Y615 Phosphorylation HPRD 15592455, 18083107
S827 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
Y283 Phosphorylation P06239 (LCK) , P00533 (EGFR) HPRD 1850098
Y438 Phosphorylation HPRD 15592455, 18083107
S650 Phosphorylation HPRD 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q05397 (PTK2) Y397 P20936 (RASA1) decreased_association eFIP 30816469
Phosphorylation Q13283 (G3BP1) S149 P20936 (RASA1) unknown eFIP 22205990


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000049846 (hPDGFRB/SigPep-/Phos:2) increased Interaction PR:P20936 (hRASA1) PRO 1653029


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S418 R418 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y438 * Biomuta DOID:363 / uterine cancer [ cosmic ]
Y615 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S650 F650 Biomuta DOID:11615 / penile cancer [ cosmic ]
S827 F827 Biomuta DOID:11615 / penile cancer [ cosmic ]