iPTMnet Report for P19623 (SRM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19623 / SPEE_HUMAN
Protein Name Spermidine synthase
Gene Name Name: SRM
Synonyms:SPS1,SRML1;
Organism Homo sapiens (Human)

PRO ID PR:P19623
DAG View
PRO Name spermidine synthase (human)
Definition A spermidine synthase that is encoded in the genome of human.
Short Label hSRM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19623 (SRM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
R17 Methylation PhosphoSitePlus
R22 Methylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
C71 S-Nitrosylation dbSNO 26338901
T72 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K253 Sumoylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K277 Sumoylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K296 Sumoylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K113 E113 Biomuta DOID:3571 / liver cancer [ cosmic ]
K134 N134 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S147 L147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]