iPTMnet Report for P19532 (TFE3)
Protein Information
UniProt AC / UniProt ID | P19532 / TFE3_HUMAN |
Protein Name | Transcription factor E3 |
Gene Name | Name: TFE3 Synonyms:BHLHE33; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P19532 |
PRO Name | transcription factor E3 (human) |
Definition | A transcription factor E3 that is encoded in the genome of human. |
Short Label | hTFE3 |
Category | organism-gene |
P19532 (TFE3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
S47 | Phosphorylation | score2 | UniProt | 36608670 | ||
K68 | Sumoylation | score1 | PhosphoSitePlus | |||
T85 | Phosphorylation | score1 | PhosphoSitePlus | |||
S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
S109 | Phosphorylation | score1 | PhosphoSitePlus | |||
S112 | Phosphorylation | score1 | PhosphoSitePlus | |||
R122 | Methylation | score1 | PhosphoSitePlus | |||
S149 | Phosphorylation | score1 | PhosphoSitePlus | |||
K178 | Methylation | score1 | PhosphoSitePlus | |||
K200 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y202 | Phosphorylation | score1 | PhosphoSitePlus | |||
T217 | Phosphorylation | score1 | PhosphoSitePlus | |||
S246 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 32662822 | ||
S321 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 24448649, 30849994, 30520728, ... | ||
K330 | Sumoylation | score1 | PhosphoSitePlus | |||
S334 | Phosphorylation | score1 | PhosphoSitePlus | |||
K339 | Ubiquitination | score1 | PhosphoSitePlus | |||
R365 | Methylation | score1 | PhosphoSitePlus | |||
K385 | Ubiquitination | score1 | PhosphoSitePlus | |||
K401 | Acetylation | score1 | PhosphoSitePlus | |||
S542 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S548 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231, 24275569 | ||
S554 | Phosphorylation | score1 | PhosphoSitePlus | |||
S556 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163, 20068231 | ||
S560 | O-Glycosylation | score1 | GlyGen | 34725712, 28657654 | ||
S560 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 17081983, 20068231 | ||
S563 | Phosphorylation | score1 | PhosphoSitePlus | |||
S564 | Phosphorylation | score1 | PhosphoSitePlus | |||
S567 | Phosphorylation | score1 | PhosphoSitePlus | |||
S568 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
S575 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T217 | Phosphorylation | score0 | HPRD | 20068231 | ||
T236 | Phosphorylation | score0 | HPRD | 20068231 | ||
S246 | Phosphorylation | score0 | HPRD | 20068231 | ||
S257 | Phosphorylation | score0 | HPRD | 20068231 | ||
S542 | Phosphorylation | score0 | HPRD | 20058876 | ||
S548 | Phosphorylation | score0 | HPRD | 19651622, 20058876, 20068231 | ||
S553 | Phosphorylation | score0 | HPRD | 17081983 | ||
S554 | Phosphorylation | score0 | HPRD | 19651622, 17081983, 20068231 | ||
S556 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 20058876, ... | ||
S560 | Phosphorylation | score0 | HPRD | 19651622, 17081983, 20068231 | ||
S568 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K68 | I68 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K68 | E68 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
K68 | T68 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
R122 | Q122 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S246 | G246 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S321 | C321 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K339 | N339 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K385 | R385 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S542 | P542 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S548 | F548 | Biomuta | [ cosmic ] | |
S568 | N568 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |