iPTMnet Report for P19484 (TFEB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19484 / TFEB_HUMAN
Protein Name Transcription factor EB
Gene Name Name: TFEB
Synonyms:BHLHE35;
Organism Homo sapiens (Human)

PRO ID PR:P19484
DAG View
PRO Name transcription factor EB (human)
Definition A transcription factor EB that is encoded in the genome of human.
Short Label hTFEB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19484 (TFEB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus   RLIMS-P 29507340
R8 Methylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S109 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S114 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 32662822, 18669648
K116 Acetylation PhosphoSitePlus
S122 Phosphorylation P42345 (MTOR) phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 18669648, 23186163, 20068231, ...28055300
S133 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S134 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S138 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 33163944, 32622269, 29992949, ...30120233, 18669648, 20068231
S142 Phosphorylation P28482 (MAPK1) , P42345 (MTOR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27278822, 21617040, 31519738, ...31750630, 33163944, 32622269, 30979895, 31112550, 29992949, 30120233, 32662822, 18669648, 31717697, 22343943, 31404503, 21804531, 31413743, 20068231, 26240184
T183 Phosphorylation PhosphoSitePlus   UniProt 20068231
S189 Phosphorylation IEDB 32387766
S211 Phosphorylation P42345 (MTOR) PhosphoSitePlus   RLIMS-P   Signor   UniProt 22576015, 33163944, 32037305, ...32881934, 30120233, 22692423, 29507340, 34405859, 30979895, 24081491, 31750630, 25720963, 29992949, 23401004, 32753672, 35662396, 32622269, 36697823, 31112550, 32208437, 28055300, 26240184
S227 Phosphorylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
R254 Methylation PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K279 Acetylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
T331 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 32662822, 18669648
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21617040, 18669648
S334 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K347 Sumoylation PhosphoSitePlus
S423 Phosphorylation IEDB   PhosphoSitePlus   UniProt 21617040, 23186163, 32897882
S429 Phosphorylation PhosphoSitePlus
K431 Acetylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus   UniProt 20068231
S455 Phosphorylation PhosphoSitePlus
S462 Phosphorylation P05771 (PRKCB) neXtProt   RLIMS-P 23599343, 31717697
S463 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   RLIMS-P 23599343, 31717697
S466 Phosphorylation PhosphoSitePlus
S467 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 33318473, 32662822, ...29689560, 23599343, 19690332
S469 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus 23599343
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation HPRD 20068231
S109 Phosphorylation HPRD 18669648, 20068231
S114 Phosphorylation HPRD 19651622, 18669648, 20068231
S122 Phosphorylation HPRD 19651622, 18669648, 20068231
S133 Phosphorylation HPRD 18669648
S134 Phosphorylation HPRD 18669648
S138 Phosphorylation HPRD 18669648, 20068231
S142 Phosphorylation HPRD 18669648, 20068231
T183 Phosphorylation HPRD 20068231
S187 Phosphorylation HPRD 20068231
S227 Phosphorylation HPRD 20068231
T330 Phosphorylation HPRD 20068231
T331 Phosphorylation HPRD 18669648
S332 Phosphorylation HPRD 19651622, 18669648, 20068231
S334 Phosphorylation HPRD 18669648, 20068231
S423 Phosphorylation HPRD 20068231
S441 Phosphorylation HPRD 20068231
S455 Phosphorylation HPRD 20058876, 20068231
S467 Phosphorylation HPRD 20068231
S469 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P19484 (TFEB) S3 Q68ED7 (Crtc1) unknown eFIP 29507340
Phosphorylation P19484 (TFEB) S467 P31749 (AKT1) unknown eFIP 29689560


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 P3 Biomuta DOID:363 / uterine cancer [ icgc ]
R8 C8 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S61 L61 Biomuta DOID:10534 / stomach cancer [ icgc ]