iPTMnet Report for P19419 (ELK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19419 / ELK1_HUMAN
Protein Name ETS domain-containing protein Elk-1
Gene Name Name: ELK1
Organism Homo sapiens (Human)

PRO ID PR:P19419
DAG View
PRO Name ETS domain-containing protein Elk-1 (human)
Definition An ETS domain-containing protein Elk-1 that is encoded in the genome of human.
Short Label hELK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19419 (ELK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y57 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K230 Sumoylation PhosphoSitePlus
K249 Sumoylation PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
T270 O-Glycosylation GlyGen 29485866, 28657654
S303 Phosphorylation PhosphoSitePlus
S304 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S324 Phosphorylation P27361 (MAPK3) phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 23186163, 18669648, 7889942, ...19690332
S326 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T336 Phosphorylation P27361 (MAPK3) PRO   Signor   UniProt 7889942
T353 Phosphorylation PhosphoSitePlus   UniProt 10637505
T363 Phosphorylation PhosphoSitePlus   UniProt 10637505
T368 Phosphorylation PhosphoSitePlus   UniProt 10637505
S383 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) , P45983 (MAPK8) , Q9UL54 (TAOK2) , P27361 (MAPK3) , O75582 (RPS6KA5) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20727996, 23322625, 20089855, ...28157711, 15899879, 8622654, 11371562, 23226423, 24712764, 8548291, 21655091, 9367995, 10637505, 29765550, 12097262, 7889942, 12665513, 9130707, 27789988, 23755307, 23114923, 29368606, 15998468, 19168130, 11145955, 30854565, 11309409, 12551909, 12514134, 23533340, 18160653, 14556286, 23158473, 8262053, 20675591, 17296730, 8887554, 20137095, 8846788, 21258408, 22433566, 26810856, 11896587, 19432968
S389 Phosphorylation Q16539 (MAPK14) , P27361 (MAPK3) , P28482 (MAPK1) , P45983 (MAPK8) , P45984 (MAPK9) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11145955, 23533340, 7889942, ...8846788, 30854565, 7651411, 12514134, 9130707, 18160653, 8262053, 8548291, 26810856, 15998468, 10637505
S416 Phosphorylation PhosphoSitePlus
T417 Phosphorylation Q13523 (PRPF4B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10799319, 23114923, 10637505
S422 Phosphorylation P27361 (MAPK3) PRO   PhosphoSitePlus   Signor   UniProt 7889942, 19690332
Site PTM Type PTM Enzyme Score Source PMID
S198 Phosphorylation HPRD 18452278
S304 Phosphorylation HPRD 18669648
S324 Phosphorylation HPRD 18669648, 20068231
S326 Phosphorylation HPRD 18669648
S383 Phosphorylation P45984 (MAPK9) , P28482 (MAPK1) , Q16539 (MAPK14) , Q9UL54 (TAOK2) HPRD 8548291, 15782123, 9130707, ...12665513, 12947314
S389 Phosphorylation Q16539 (MAPK14) , P45984 (MAPK9) HPRD 8548291, 9130707


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047277 (hELK1/Phos:1) pS324,pT336,pS383,pS389,pS422 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P19419 (ELK1) S389 Q09472 (EP300) unknown eFIP 12514134
Phosphorylation Q02535 (ID3) S5 P19419 (ELK1) unknown eFIP 25693514


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y57 N57 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S166 F166 Biomuta DOID:1324 / lung cancer [ cosmic ]
S194 L194 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S196 R196 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S303 Y303 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S324 N324 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S383 T383 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S389 N389 Biomuta DOID:9256 / colorectal cancer [ cosmic ]