Protein Information

Cytoscape View


UniProt AC / UniProt ID P18846 / ATF1_HUMAN
Protein Name Cyclic AMP-dependent transcription factor ATF-1
Gene Name Name: ATF1
Organism Homo sapiens (Human)

PRO ID PR:P18846
DAG View
PRO Name cyclic AMP-dependent transcription factor ATF-1 (human)
Definition A cyclic AMP-dependent transcription factor ATF-1 that is encoded in the genome of human.
Short Label hATF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18846 (ATF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation P68400 (CSNK2A1) , P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 9685505, 18669648, 8414969, ...20730097, 8600455
S38 Phosphorylation P68400 (CSNK2A1) Signor 20730097
S41 Phosphorylation P48729 (CSNK1A1) , P68400 (CSNK2A1) PhosphoSitePlus   Signor 20730097
S44 Phosphorylation P68400 (CSNK2A1) Signor 20730097
S47 Phosphorylation P48729 (CSNK1A1) , P68400 (CSNK2A1) PhosphoSitePlus 20730097
S50 Phosphorylation P48729 (CSNK1A1) , P68400 (CSNK2A1) PhosphoSitePlus 20730097
S51 Phosphorylation P48729 (CSNK1A1) , P68400 (CSNK2A1) PhosphoSitePlus 20730097
S63 Phosphorylation O75676 (RPS6KA4) , Q00526 (CDK3) , Q14012 (CAMK1) , P51812 (RPS6KA3) , O75582 (RPS6KA5) , P68400 (CSNK2A1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 12414794, 28032861, 18690222, ...11335727, 20980392, 8621702, 11909979, 9016641, 20089855, 18794154, 8663317, 35397606, 21098035, 23220124, 19369332
Y64 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
T154 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
S164 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T183 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 32938750, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T183 Phosphorylation phospho.ELM 18669648
T184 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T184 Phosphorylation PhosphoSitePlus   RLIMS-P 28032861
S186 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
S186 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T188 O-Glycosylation GlyGen 30379171
T188 Phosphorylation phospho.ELM 18669648
S189 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 33214551, 30379171, ...32574038, 32938750, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T193 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T197 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T197 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S198 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
S198 Phosphorylation Q9H2X6 (HIPK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28032861, 23186163, 20980392, ...18669648, 19690332
T201 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T203 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
S204 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T206 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T207 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 30620550, 31492838, 29485866, 35289036, 29351928, 15327282, 36240223, 20068230
T209 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
R244 Methylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation P68400 (CSNK2A1) HPRD 18669648, 18452278, 9685505
S47 Phosphorylation HPRD 18452278
S63 Phosphorylation O75676 (RPS6KA4) , O75582 (RPS6KA5) , Q14012 (CAMK1) , Q13555 (CAMK2G) , P17612 (PRKACA) HPRD 8663317, 20068231
T183 Phosphorylation HPRD 18669648, 20068231
S186 Phosphorylation HPRD 18669648, 20068231
T188 Phosphorylation HPRD 18669648
T197 Phosphorylation HPRD 18669648, 20068231
S198 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S44 A44 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S47 N47 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S47 T47 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y64 C64 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K263 M263 Biomuta DOID:184 / bone cancer [ cosmic ]