iPTMnet Report for P18754 (RCC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P18754 / RCC1_HUMAN
Protein Name Regulator of chromosome condensation
Gene Name Name: RCC1
Synonyms:CHC1;
Organism Homo sapiens (Human)

PRO ID PR:P18754
DAG View
PRO Name regulator of chromosome condensation (human)
Definition A regulator of chromosome condensation that is encoded in the genome of human.
Short Label hRCC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18754 (RCC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Methylation UniProt 20668449, 17435751, 18762580
S2 Phosphorylation Q13188 (STK3) , P06493 (CDK1) neXtProt   PhosphoSitePlus   Signor   UniProt 19559616, 18568422, 15014043, ...17435751
S11 Phosphorylation P06493 (CDK1) , Q13188 (STK3) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17322306, 21406692, 19559616, ...23186163, 17081983, 29042532, 15014043, 15302935, 15203004, 18452278, 19651622, 18669648, 24275569, 34356619, 17287340, 18568422, 20068231, 20068230
S20 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
C93 S-Nitrosylation dbSNO 26338901
S104 Phosphorylation PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S145 O-Glycosylation GlyGen 33214551, 29351928, 30620550, ...34019948, 32119511, 28510447, 34229054
K160 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
R214 Methylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
T274 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 18568422, 15014043
T306 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
K335 Sumoylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S336 O-Glycosylation GlyGen 33214551, 29351928, 30620550, ...34019948, 32119511, 28510447, 34229054
S336 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S387 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 18568422, 15014043
S403 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
S405 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
S406 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
T411 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation P06493 (CDK1) HPRD 15014043
S11 Phosphorylation HPRD 17322306, 17287340, 18767875, ...18452278, 19651622, 18669648, 20068231, 20068230
S405 Phosphorylation HPRD 16964243
S406 Phosphorylation HPRD 16964243
T411 Phosphorylation HPRD 16964243
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD   PhosphoSitePlus 17322306, 17287340, 18452278, ...19651622, 18669648, 20068231, 20068230
S47 Phosphorylation PhosphoSitePlus
S436 Phosphorylation HPRD 16964243
S437 Phosphorylation HPRD 16964243
T442 Phosphorylation HPRD 16964243


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 T2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S26 L26 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S90 F90 Biomuta DOID:4159 / skin cancer [ cosmic ]
K160 R160 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R214 G214 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R214 H214 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S311 L311 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S336 N336 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S403 C403 Biomuta DOID:1324 / lung cancer [ cosmic ]
S403 Y403 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S405 F405 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S436 F436 Biomuta DOID:9256 / colorectal cancer [ cosmic ]