iPTMnet Report for P18146 (EGR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P18146 / EGR1_HUMAN
Protein Name Early growth response protein 1
Gene Name Name: EGR1
Synonyms:KROX24,ZNF225;
Organism Homo sapiens (Human)

PRO ID PR:P18146
DAG View
PRO Name early growth response protein 1 (human)
Definition An early growth response protein 1 that is encoded in the genome of human.
Short Label hEGR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18146 (EGR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus   RLIMS-P 30711252
S26 Phosphorylation PhosphoSitePlus   RLIMS-P 35041980, 30711252
S104 Phosphorylation PhosphoSitePlus
T119 O-Glycosylation GlyGen 30379171, 35254053, 29351928, ...35289036, 30620550, 28657654, 20068230
S120 O-Glycosylation GlyGen   PhosphoSitePlus 34846842, 30379171, 29351928, ...30620550, 35289036, 35254053, 28657654, 20068230
S123 O-Glycosylation GlyGen 30379171, 35254053, 29351928, ...35289036, 30620550, 28657654, 20068230
T125 O-Glycosylation GlyGen 30379171, 35254053, 29351928, ...35289036, 30620550, 28657654, 20068230
T126 O-Glycosylation GlyGen 30379171, 35254053, 29351928, ...35289036, 30620550, 28657654, 20068230
T132 O-Glycosylation GlyGen 30379171, 35254053, 29351928, ...35289036, 30620550, 28657654, 20068230
T148 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S222 Phosphorylation IEDB 35494241
K272 Sumoylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
S350 Phosphorylation IEDB 29493099
C370 Methylation IEDB 31844290
S378 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus 8662759
T389 Phosphorylation PhosphoSitePlus
T391 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus 8662759
S444 Phosphorylation IEDB 29493099
S501 Phosphorylation RLIMS-P 35103892
T526 Phosphorylation P68400 (CSNK2A1) HPRD 8662759


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S120 I120 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T126 A126 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T148 N148 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S350 P350 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T389 I389 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T391 K391 Biomuta DOID:1612 / breast cancer [ cosmic ]