iPTMnet Report for P17600 (SYN1)
Protein Information
| UniProt AC / UniProt ID | P17600 / SYN1_HUMAN |
| Protein Name | Synapsin-1 |
| Gene Name | Name: SYN1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P17600 |
| PRO Name | synapsin-1 (human) |
| Definition | A synapsin-1 that is encoded in the genome of human. |
| Short Label | hSYN1 |
| Category | organism-gene |
DAG ViewP17600 (SYN1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S9 | Phosphorylation | Q14012 (CAMK1) , Q13131 (PRKAA1) | score4 | neXtProt PhosphoSitePlus Signor | 10880969, 8022798 | |
| S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S39 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15822905 | ||
| S62 | Phosphorylation | P27361 (MAPK3) | score3 | neXtProt PhosphoSitePlus | 8622996 | |
| S67 | Phosphorylation | P27361 (MAPK3) | score3 | neXtProt PhosphoSitePlus | 8622996 | |
| T87 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
| T262 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
| T263 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
| S293 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y301 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 20530578 | ||
| S332 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S427 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15822905 | ||
| S432 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T436 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S438 | Phosphorylation | Q8TAS1 (UHMK1) | score3 | phospho.ELM PhosphoSitePlus Signor | 10880969 | |
| T448 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S449 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S551 | Phosphorylation | P27361 (MAPK3) , Q00535 (CDK5) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 10880969, 8622996, ... | |
| S553 | Phosphorylation | Q00535 (CDK5) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 8702879, 21406692, 15822905, ... | |
| T567 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S568 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
| S568 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S605 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus | 12237306, 17525332, 15822905 | ||
| T613 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T618 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
| S698 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S9 | Phosphorylation | Q13177 (PAK2) , Q14012 (CAMK1) , P17612 (PRKACA) | score2 | HPRD | 12237306, 9395448, 10571231 | |
| S62 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S67 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S510 | Phosphorylation | score0 | HPRD | 15345747 | ||
| S551 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S553 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S568 | Phosphorylation | Q13555 (CAMK2G) | score1 | HPRD | 3118371 | |
| S605 | Phosphorylation | Q13153 (PAK1) , Q13555 (CAMK2G) , O75914 (PAK3) | score2 | HPRD | 12237306, 3118371 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S9 | Phosphorylation | Q14012 (CAMK1) , P17612 (PRKACA) , Q13177 (PAK2) | score2 | HPRD | 12237306, 10571231 | |
| S62 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S67 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S510 | Phosphorylation | score0 | HPRD | 15345747 | ||
| S551 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S553 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 8702879 | |
| S568 | Phosphorylation | Q13555 (CAMK2G) | score1 | HPRD | 3118371 | |
| S605 | Phosphorylation | Q13153 (PAK1) , O75914 (PAK3) , Q13555 (CAMK2G) | score2 | HPRD | 12237306, 3118371 | |
| S641 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T436 | P436 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| T448 | A448 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| T567 | A567 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| T618 | K618 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
