iPTMnet Report for P17302 (GJA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17302 / CXA1_HUMAN
Protein Name Gap junction alpha-1 protein
Gene Name Name: GJA1
Synonyms:GJAL;
Organism Homo sapiens (Human)

PRO ID PR:P17302
DAG View
PRO Name gap junction alpha-1 protein (human)
Definition A gap junction alpha-1 protein that is encoded in the genome of human.
Short Label hGJA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17302 (GJA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
R148 Methylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 32956670, 33255329, 11514593, ...18649180, 14681032, 12064600, 23060544, 18083107, 19901323, 16916748
Y247 Phosphorylation P12931 (SRC) HPRD   Signor 19901323, 11514593, 16916748
T250 Phosphorylation PhosphoSitePlus
S251 Phosphorylation HPRD   PhosphoSitePlus 19664994
S255 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21406692, 22028470, 9535909, ...12637502, 15605363, 26161412, 19664994, 9472011, 25584940, 8631994, 19258009, 26063728
S255 Phosphorylation P06493 (CDK1) RLIMS-P+ 9472011
S255 Phosphorylation P27361 (MAPK3) HPRD   neXtProt   Signor 19664994, 9535909, 12637502, ...8631994
S255 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   Signor 22028470, 19664994, 9535909, ...12637502, 8631994
S255 Phosphorylation Q13164 (MAPK7) HPRD   neXtProt   Signor 19664994, 9535909, 12637502, ...8631994
K258 Ubiquitination PhosphoSitePlus
S262 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24815185, 14702389, 16718370, ...18649180, 15605363, 23882217, 18930794, 22608771, 19258009, 26063728, 22960107
S262 Phosphorylation P17252 (PRKCA) Signor 14702389
K264 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation HPRD   IntAct   PRO   PhosphoSitePlus   RLIMS-P   Signor 32956670, 33255329, 11514593, ...18649180, 14681032, 16916748, 29587860, 12064600, 30095367, 35949588, 33080786, 26033246, 11035005
Y265 Phosphorylation P12931 (SRC) HPRD   PhosphoSitePlus   Signor 11514593, 16916748, 11035005
Y267 Phosphorylation PhosphoSitePlus   RLIMS-P 32956670
S272 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
S279 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17555745, 9535909, 12637502, ...15605363, 18047584, 15958277, 24399133, 17551925, 35949588, 8631994, 24742583, 26063728, 23363606, 9535905, 26033246, 12483281
S279 Phosphorylation P27361 (MAPK3) HPRD   neXtProt   Signor 9535905, 9535909, 12637502, ...8631994
S279 Phosphorylation P28482 (MAPK1) Signor 9535909
S279 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 18047584
S282 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17555745, 9535909, 12637502, ...15605363, 18047584, 17551925, 24399133, 24742583, 8631994, 15958277, 26063728, 23363606, 9535905, 26033246, 12483281
S282 Phosphorylation P27361 (MAPK3) HPRD   neXtProt   Signor 9535905, 9535909, 8631994
S282 Phosphorylation P28482 (MAPK1) HPRD   Signor 9535905, 9535909, 12637502, ...8631994
S282 Phosphorylation Q13164 (MAPK7) HPRD 9535905, 12637502, 8631994
S282 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 18047584
Y286 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus   RLIMS-P 19879542
S297 Phosphorylation PhosphoSitePlus   RLIMS-P 19879542
Y301 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S306 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 19879542, 18578522
Y313 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 32956670, 33255329, 19901323, ...18083107
S314 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19664994
S325 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 12270943, 16882687
S325 Phosphorylation P48730 (CSNK1D) HPRD 12270943
T326 Phosphorylation HPRD   PhosphoSitePlus 18578522
S328 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 12270943, 16882687
S328 Phosphorylation P48730 (CSNK1D) HPRD 12270943
S330 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 12270943, 18578522, 16882687
S330 Phosphorylation P48730 (CSNK1D) HPRD 12270943, 18578522
S344 Phosphorylation PhosphoSitePlus   UniProt 21406692
K345 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus   RLIMS-P 12349910, 10871288
S365 Phosphorylation HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 33255329, 16474210, 12417300, ...18578522
S365 Phosphorylation P17612 (PRKACA) neXtProt 16474210
S365 Phosphorylation Q02156 (PRKCE) Signor 16474210
S368 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 33384302, 20118409, 30104974, ...33097557, 16474210, 29223529, 14973142, 25868858, 18665255, 12697837, 28559397, 18649180, 28518143, 29587860, 30356673, 12601045, 19258009, 24612377, 20338032, 35742818, 21273554, 15534005, 28176351, 25952184, 24500718, 20074329, 24742583, 28910394, 10871288, 30621602, 26063728, 26285688, 21532342, 15459208, 21630325, 26161412, 22135478, 19454861, 23978459, 20345849, 15642736, 16709897, 17210245, 23112846, 35949588
S368 Phosphorylation P05129 (PRKCG) HPRD   neXtProt 15459208, 12601045, 15642736, ...10871288
S368 Phosphorylation P05771 (PRKCB) HPRD 10871288
S368 Phosphorylation P17252 (PRKCA) HPRD 10871288
S368 Phosphorylation P17612 (PRKACA) neXtProt 16474210
S368 Phosphorylation Q02156 (PRKCE) neXtProt   PhosphoSitePlus 21273554, 15534005
S368 Phosphorylation Q05655 (PRKCD) neXtProt 20338032
S369 Phosphorylation HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 12417300, 16474210, 31266855, ...18163231, 29259079
S369 Phosphorylation P17612 (PRKACA) neXtProt 16474210
S369 Phosphorylation P31749 (AKT1) neXtProt 18163231
S369 Phosphorylation Q02156 (PRKCE) Signor 16474210
S372 Phosphorylation PhosphoSitePlus
S373 Phosphorylation HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 33255329, 24213533, 33097557, ...12417300, 29587860, 24563481, 31266855, 35949588, 16474210, 18163231, 29259079, 24508467
S373 Phosphorylation P17612 (PRKACA) neXtProt 16474210
S373 Phosphorylation P31749 (AKT1) neXtProt 18163231
S373 Phosphorylation Q02156 (PRKCE) Signor 16474210


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047538 (hGJA1/InitMet-/Phos:2) pY265 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P17302 (GJA1) Y247 Q16643 (DBN1) inhibited_association eFIP 30448479
Phosphorylation P17302 (GJA1) S279 P05549 (TFAP2A) increased_association eFIP 23363606