iPTMnet Report for P16989 (YBX3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16989 / YBOX3_HUMAN
Protein Name Y-box-binding protein 3
Gene Name Name: YBX3
Synonyms:CSDA,DBPA;
Organism Homo sapiens (Human)

PRO ID PR:P16989
DAG View
PRO Name Y-box-binding protein 3 (human)
Definition A Y-box-binding protein 3 that is encoded in the genome of human.
Short Label hYBX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16989 (YBX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
T8 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
S34 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 16094384
S38 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S72 Phosphorylation phospho.ELM 18669648
S79 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K84 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus 21851590
T112 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K113 Acetylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
R133 Methylation PhosphoSitePlus
S134 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 32387766, 19690332, ...21368869
K150 Ubiquitination PhosphoSitePlus
R169 Methylation PhosphoSitePlus
R174 Methylation PhosphoSitePlus
R175 Methylation PhosphoSitePlus
R176 Methylation PhosphoSitePlus
R179 Methylation IEDB   PhosphoSitePlus 27503676
Y182 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S203 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
T212 Phosphorylation PhosphoSitePlus
R220 Methylation PhosphoSitePlus
R224 Methylation PhosphoSitePlus
R225 Methylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
R229 Methylation PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
R233 Methylation PhosphoSitePlus
R235 Methylation PhosphoSitePlus
R236 Methylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
R251 Methylation PhosphoSitePlus   UniProt 24129315
R258 Methylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
R283 Methylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
R288 Methylation PhosphoSitePlus
R290 Methylation PhosphoSitePlus
R292 Methylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
R294 Methylation PhosphoSitePlus
R298 Methylation PhosphoSitePlus
R300 Methylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
T317 O-Glycosylation GlyGen 31373491
T317 Phosphorylation PhosphoSitePlus
S318 O-Glycosylation GlyGen 31373491
S318 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
R326 Methylation PhosphoSitePlus   UniProt 24129315
R327 Methylation PhosphoSitePlus
R330 Methylation PhosphoSitePlus
R331 Methylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
R336 Methylation PhosphoSitePlus
R337 Methylation PhosphoSitePlus
R338 Methylation PhosphoSitePlus
R340 Methylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
T359 O-Glycosylation GlyGen 31373491
T366 O-Glycosylation GlyGen 34019948, 31373491
T366 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330, 18491316, 20068231
T8 Phosphorylation HPRD 18491316
T14 Phosphorylation HPRD 18491316
S34 Phosphorylation HPRD 19413330, 18669648, 15302935
S38 Phosphorylation HPRD 19413330, 18669648
T65 Phosphorylation HPRD 20068231
S72 Phosphorylation HPRD 18669648
S79 Phosphorylation HPRD 19413330, 18669648
S134 Phosphorylation HPRD 19651622, 18669648, 17081983
Y192 Phosphorylation HPRD 17081983
S201 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19664995
S203 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231, 18452278
S204 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S369 Phosphorylation HPRD 19413330, 20068231
S370 Phosphorylation HPRD 19413330, 19651622, 19664995, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
K199 Ubiquitination PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K96 R96 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K113 N113 Biomuta DOID:363 / uterine cancer [ icgc ]
Y131 N131 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S134 N134 Biomuta DOID:4159 / skin cancer [ cosmic ]
R169 C169 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R174 W174 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R175 H175 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
R176 H176 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R176 C176 Biomuta DOID:3571 / liver cancer [ cosmic ]
R220 W220 Biomuta DOID:1324 / lung cancer [ cosmic ]
R220 Q220 Biomuta DOID:363 / uterine cancer [ icgc ]
R224 H224 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R224 C224 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R225 L225 Biomuta DOID:1612 / breast cancer [ cosmic ]
R225 H225 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
R229 H229 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R229 L229 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R229 C229 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
R233 W233 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R236 W236 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R236 Q236 Biomuta DOID:4159 / skin cancer [ cosmic ]
R251 W251 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R283 Q283 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R288 H288 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R292 C292 Biomuta DOID:1319 / brain cancer [ cosmic ]
R298 H298 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R300 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R300 Q300 Biomuta DOID:1319 / brain cancer [ icgc ]
R326 C326 Biomuta DOID:4159 / skin cancer [ cosmic ]
R327 L327 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R327 H327 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R330 W330 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R330 Q330 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R331 C331 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R337 H337 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R338 H338 Biomuta DOID:363 / uterine cancer [ icgc ]
R340 H340 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K350 N350 Biomuta DOID:263 / kidney cancer [ cosmic ]