iPTMnet Report for P16118 (PFKFB1)
Protein Information
UniProt AC / UniProt ID | P16118 / F261_HUMAN |
Protein Name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 |
Gene Name | Name: PFKFB1 Synonyms:F6PK,PFRX; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P16118 |
PRO Name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (human) |
Definition | A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is encoded in the genome of human. |
Short Label | hPFKFB1 |
Category | organism-gene |
P16118 (PFKFB1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | O-Glycosylation | score1 | GlyGen | 29485866, 28411811, 35254053 | ||
S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
T9 | O-Glycosylation | score1 | GlyGen | 29485866, 28411811, 35254053 | ||
S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
T39 | Phosphorylation | score1 | PhosphoSitePlus | |||
T133 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y200 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y204 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y227 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y242 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y243 | Phosphorylation | score1 | PhosphoSitePlus | |||
S262 | Phosphorylation | score1 | PhosphoSitePlus | |||
K364 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y438 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000026776 (hPFKFB1/InitMet-/Phos:1) | pS33 | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y204 | C204 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y243 | H243 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc, tcga ] | |
K364 | N364 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |