iPTMnet Report for P15941 (MUC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15941 / MUC1_HUMAN
Protein Name Mucin-1 precursor
Gene Name Name: MUC1
Synonyms:PUM;
Organism Homo sapiens (Human)

PRO ID PR:P15941
DAG View
PRO Name mucin-1 (human)
Definition A mucin-1 that is encoded in the genome of human.
Short Label hMUC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15941 (MUC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 O-Glycosylation GlyGen 25813380
T30 O-Glycosylation GlyGen 25813380
S130 O-Glycosylation GlyGen 33214551, 35132862, 30059200
T131 O-Glycosylation GlyGen   IEDB   UniProt 33214551, 33211039, 35132862, ...9597769, 7744025, 30059200
T139 O-Glycosylation GlyGen   UniProt 33214551, 7744025, 35132862, ...9597769, 30059200
T144 O-Glycosylation IEDB 28025250
T239 O-Glycosylation GlyGen 33214551, 35132862, 30059200
T279 O-Glycosylation GlyGen 33214551, 35132862, 30059200
T911 O-Glycosylation GlyGen 30459171
T919 O-Glycosylation GlyGen 30459171
T924 O-Glycosylation GlyGen 30459171
S930 O-Glycosylation GlyGen 30459171
S989 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T990 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S993 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S999 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T1001 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T1003 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T1004 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S1009 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T1010 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N1055 N-Glycosylation GlyGen 29741879
S1090 Phosphorylation PhosphoSitePlus
K1125 Acetylation PhosphoSitePlus
Y1191 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T1202 Phosphorylation PhosphoSitePlus
Y1203 Phosphorylation P09619 (PDGFRB) , P43403 (ZAP70) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14521915, 14766232, 15471854, ...18083107, 17545600
S1207 Phosphorylation PhosphoSitePlus
Y1209 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T1211 Phosphorylation PhosphoSitePlus
Y1212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 14521915
T1214 Phosphorylation PhosphoSitePlus
Y1218 Phosphorylation P09619 (PDGFRB) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18083107, 17545600
S1222 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
T1224 Phosphorylation Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11877440
S1227 Phosphorylation P49841 (GSK3B) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 9819408, 23186163
Y1229 Phosphorylation P06239 (LCK) , P07948 (LYN) , P00533 (EGFR) , P12931 (SRC) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14521915, 14766232, 12750561, ...11152665, 18083107, 17545600, 11483589
S1233 Phosphorylation PhosphoSitePlus
S1240 Phosphorylation PhosphoSitePlus
S1242 Phosphorylation PhosphoSitePlus
Y1243 Phosphorylation P00519 (ABL1) , A0A173G4P4 (Abl fusion) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18083107, 14521915, 16888623, ...7664271
T1244 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation HPRD 18083107
Y151 Phosphorylation HPRD 18083107
Y157 Phosphorylation HPRD 18083107
Y160 Phosphorylation HPRD 18083107
Y177 Phosphorylation HPRD 18083107
Y191 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
Y200 Phosphorylation HPRD 18083107
Y212 Phosphorylation HPRD 18083107
Y218 Phosphorylation HPRD 18083107
Y221 Phosphorylation HPRD 18083107
T233 Phosphorylation Q05655 (PRKCD) HPRD 11877440
S236 Phosphorylation P49841 (GSK3B) HPRD 9819408
Y238 Phosphorylation P43403 (ZAP70) , P00533 (EGFR) HPRD 11152665, 14766232, 11483589
Y252 Phosphorylation HPRD 7664271, 15471854
Site PTM Type PTM Enzyme Score Source PMID
Y95 Phosphorylation HPRD 18083107
Y107 Phosphorylation HPRD 18083107
Y113 Phosphorylation HPRD 18083107
Y116 Phosphorylation HPRD 18083107
Y133 Phosphorylation HPRD 18083107
Y147 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y191 Phosphorylation HPRD 18083107
Y203 Phosphorylation HPRD 18083107
Y209 Phosphorylation HPRD 18083107
Y212 Phosphorylation HPRD 18083107
T224 Phosphorylation Q05655 (PRKCD) HPRD 11877440
S227 Phosphorylation P49841 (GSK3B) HPRD 9819408
Y229 Phosphorylation P00533 (EGFR) , P43403 (ZAP70) HPRD 14766232, 11152665, 11483589
Y243 Phosphorylation HPRD 7664271, 15471854
Site PTM Type PTM Enzyme Score Source PMID
Y209 Phosphorylation HPRD 18083107
Y221 Phosphorylation HPRD 18083107
Y227 Phosphorylation HPRD 18083107
Y230 Phosphorylation HPRD 18083107
T242 Phosphorylation Q05655 (PRKCD) HPRD 11877440
S245 Phosphorylation P49841 (GSK3B) HPRD 9819408
Y247 Phosphorylation P00533 (EGFR) HPRD 11483589
Y261 Phosphorylation HPRD 7664271


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q05655 (PRKCD) T507 P15941 (MUC1) increased_association eFIP 28692035


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 G47 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S47 R47 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y113 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y116 F116 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y157 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y160 F160 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y209 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y212 F212 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y218 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y221 F221 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y227 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y230 F230 Biomuta DOID:263 / kidney cancer [ cosmic ]