iPTMnet Report for P15927 (RPA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15927 / RFA2_HUMAN
Protein Name Replication protein A 32 kDa subunit
Gene Name Name: RPA2
Synonyms:REPA2,RPA32,RPA34;
Organism Homo sapiens (Human)

PRO ID PR:P15927
DAG View
PRO Name replication protein A 32 kDa subunit (human)
Definition A replication protein A 32 kDa subunit that is encoded in the genome of human.
Short Label hRPA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15927 (RPA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 9139719, 20068231
S4 Phosphorylation P78527 (PRKDC) , Q8N2W9 (PIAS4) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26721387, 22037398, 19713747, ...26474068, 9295339, 26271993, 20016603, 24253929, 18289945, 22977173, 21731742, 25249630, 30237520, 27999209, 29875999, 26684013, 23319600, 31582797, 23897887, 24819595
S8 Phosphorylation P78527 (PRKDC) , Q8N2W9 (PIAS4) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26721387, 22037398, 26474068, ...26271993, 9295339, 24819595, 20016603, 24253929, 18289945, 22977173, 19713747, 25249630, 30237520, 27999209, 29875999, 26684013, 23319600, 31582797, 23897887, 21731742
Y9 Phosphorylation PhosphoSitePlus
S11 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 9295339, 22977173, 18669648
S12 Phosphorylation P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   RLIMS-P+ 9295339, 22977173
S13 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 9295339, 22977173, 18669648
Y14 Phosphorylation PhosphoSitePlus
T21 Phosphorylation Q13315 (ATM) , P78527 (PRKDC) , Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26474068, 24253929, 17035231, ...9295339, 9139719, 15060176, 28666352, 21558276, 22977173, 14872059, 30237520, 29875999, 31582797
S23 Phosphorylation Q00535 (CDK5) , P24941 (CDK2) , Q13535 (ATR) , P06493 (CDK1) , P78527 (PRKDC) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 1318195, 8246944, 26271993, ...19671522, 22977173, 21731742, 26237679, 9295339, 20068231
S29 Phosphorylation Q13315 (ATM) , Q00535 (CDK5) , Q13535 (ATR) , P24941 (CDK2) , P78527 (PRKDC) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 17928296, 1318195, 8246944, ...26271993, 19671522, 9139719, 22977173, 21731742, 20068231, 26237679, 9295339, 29875999, 21664290
S33 Phosphorylation Q13535 (ATR) , P06493 (CDK1) , P24941 (CDK2) , P78527 (PRKDC) , Q00535 (CDK5) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26845351, 20639859, 9139719, ...23684611, 26474068, 22977173, 25249630, 26237679, 31582797, 23319600, 33820915, 26057167, 9295339, 17035231, 24253929, 26271993, 28666352, 36384122, 19843584, 25070753, 23897887
K37 Ubiquitination PhosphoSitePlus   UniProt 26474068
K38 Ubiquitination PhosphoSitePlus   UniProt 26474068
S39 Phosphorylation phospho.ELM 18669648
C49 Methylation IEDB 31844290
S52 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus 10608806, 17035231
S72 Phosphorylation Q13535 (ATR) PhosphoSitePlus 17035231
K85 Ubiquitination PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
R105 Methylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
R133 Methylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S174 Phosphorylation Q13535 (ATR) PhosphoSitePlus 17035231
K231 Acetylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation P78527 (PRKDC) HPRD 9295339
S8 Phosphorylation P78527 (PRKDC) HPRD 9295339
S11 Phosphorylation P78527 (PRKDC) HPRD 9295339, 18669648
S12 Phosphorylation P78527 (PRKDC) HPRD 9295339
S13 Phosphorylation P78527 (PRKDC) HPRD 9295339, 18669648
T21 Phosphorylation P78527 (PRKDC) HPRD 9295339
S23 Phosphorylation P06493 (CDK1) HPRD 9295339, 20068231
S29 Phosphorylation P06493 (CDK1) HPRD 9295339, 20068231
S33 Phosphorylation P78527 (PRKDC) HPRD 9295339
S39 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049064 (hRPA2/Phos:2) pS33 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y9 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y14 N14 Biomuta DOID:1612 / breast cancer [ cosmic ]
S23 F23 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S29 L29 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K37 N37 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S39 A39 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S52 F52 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K85 N85 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K85 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R105 C105 Biomuta DOID:4159 / skin cancer [ cosmic ]
R133 S133 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]