iPTMnet Report for P15923 (TCF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15923 / TFE2_HUMAN
Protein Name Transcription factor E2-alpha
Gene Name Name: TCF3
Synonyms:BHLHB21,E2A,ITF1;
Organism Homo sapiens (Human)

PRO ID PR:P15923
DAG View
PRO Name transcription factor E2-alpha (human)
Definition A transcription factor E2-alpha that is encoded in the genome of human.
Short Label hTCF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15923 (TCF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T12 Phosphorylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
S39 Phosphorylation Q9P286 (PAK5) PhosphoSitePlus   RLIMS-P 26212009
S48 Phosphorylation neXtProt 11114297
T74 O-Glycosylation GlyGen 34019948, 35132862, 35254053
R105 Methylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus   UniProt 20068231
S139 Phosphorylation Q16539 (MAPK14) , Q15759 (MAPK11) , P11802 (CDK4) , P24941 (CDK2) neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 15719023, 11114297, 19690332
S141 Phosphorylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
S245 Phosphorylation P11802 (CDK4) , P24941 (CDK2) neXtProt   PhosphoSitePlus 11114297
S312 O-Glycosylation GlyGen 34019948, 35132862, 35254053
S316 O-Glycosylation GlyGen 34019948, 35132862, 35254053
S341 Phosphorylation Q02779 (MAP3K10) PhosphoSitePlus   Signor 19801649
S345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S352 Phosphorylation Q02779 (MAP3K10) PhosphoSitePlus   Signor 19801649
S354 Phosphorylation PhosphoSitePlus
T355 Phosphorylation Q02779 (MAP3K10) IEDB   phospho.ELM   PhosphoSitePlus   Signor 32387766, 14592976, 19801649
S359 Phosphorylation Q02779 (MAP3K10) PhosphoSitePlus   Signor   UniProt 19690332, 19801649
T366 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
R371 Methylation PhosphoSitePlus
S379 Phosphorylation Q02779 (MAP3K10) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 23186163, 19801649
S381 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y382 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K392 Sumoylation PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
K498 Sumoylation PhosphoSitePlus
K502 Sumoylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
S529 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
D531 Phosphorylation UniProt 18669648
K570 Ubiquitination PhosphoSitePlus
C576 Methylation IEDB 31844290
K584 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S134 Phosphorylation HPRD 20068231
S139 Phosphorylation HPRD 20068231
S306 Phosphorylation HPRD 20068231
T355 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 14592976
S379 Phosphorylation HPRD 19651622, 18669648, 20068231
S381 Phosphorylation HPRD 19651622, 18669648, 20068231
Y382 Phosphorylation HPRD 18669648
S514 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
Y149 Phosphorylation PhosphoSitePlus
S352 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 12810726
T355 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 12810726
S359 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 12810726
S379 Phosphorylation phospho.ELM 18669648
S381 Phosphorylation phospho.ELM 18669648
Y382 Phosphorylation phospho.ELM 18669648
T528 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049407 (hTCF3/Phos:2) pS139 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P17542 (TAL1) S172 P15923 (TCF3) unknown eFIP 9111058


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S39 F39 Biomuta DOID:4159 / skin cancer [ cosmic ]
S39 I39 Biomuta DOID:4159 / skin cancer [ cosmic ]
R105 Q105 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R105 W105 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y108 H108 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S134 N134 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S139 F139 Biomuta DOID:4159 / skin cancer [ cosmic ]
S141 L141 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y153 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y153 C153 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S346 N346 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S359 F359 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R371 Q371 Biomuta DOID:11615 / penile cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R371 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T411 I411 Biomuta DOID:3119 / gastrointestinal system cancer [ cosmic ]
K502 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S514 L514 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S579 L579 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K614 T614 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]