iPTMnet Report for P15374 (UCHL3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15374 / UCHL3_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L3
Gene Name Name: UCHL3
Organism Homo sapiens (Human)

PRO ID PR:P15374
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase isozyme L3 (human)
Definition A ubiquitin carboxyl-terminal hydrolase isozyme L3 that is encoded in the genome of human.
Short Label hUCHL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15374 (UCHL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S75 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 36142702, 20068231, ...30559450
T81 Phosphorylation HPRD 20068231
S82 Phosphorylation HPRD 20068231
Y85 Phosphorylation HPRD 20068231
T97 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
S130 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 18669648, 23186163, ...24275569
Y141 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P15374 (UCHL3) S75 P13010 (XRCC5) unknown eFIP 30559450


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K121 E121 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S130 I130 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S151 I151 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S161 R161 Biomuta DOID:4159 / skin cancer [ cosmic ]
S161 I161 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]