iPTMnet Report for P15336 (ATF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15336 / ATF2_HUMAN
Protein Name Cyclic AMP-dependent transcription factor ATF-2
Gene Name Name: ATF2
Synonyms:CREB2,CREBP1;
Organism Homo sapiens (Human)

PRO ID PR:P15336
DAG View
PRO Name cyclic AMP-dependent transcription factor ATF-2 (human)
Definition A cyclic AMP-dependent transcription factor ATF-2 that is encoded in the genome of human.
Short Label hATF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15336 (ATF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation RLIMS-P 26883894
K46 Ubiquitination PhosphoSitePlus
T52 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23589174, 26645581, 22304920, ...25728676
S62 Phosphorylation P17612 (PRKACA) , Q99986 (VRK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 1661585, 23186163, 15105425, ...28918037
T69 Phosphorylation P45984 (MAPK9) , P45983 (MAPK8) , P53778 (MAPK12) , P27361 (MAPK3) , Q9H4B4 (PLK3) , Q16539 (MAPK14) , P28482 (MAPK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 16049073, 33188182, 16601071, ...19176525, 11078583, 9029150, 19822663, 15304344, 9430721, 7737130, 21406692, 23186163, 20562914, 12110590, 7824938, 10085140, 19690332, 24118792, 25545367, 7535770, 15105425, 12833146, 25041846, 21098032, 32993798, 19647037, 24982422, 10777545, 11259436, 18669648, 20140229, 20068231, 7737129
T71 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) , P45984 (MAPK9) , P27361 (MAPK3) , P45983 (MAPK8) , Q9H4B4 (PLK3) , P53778 (MAPK12) neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 16049073, 33188182, 16601071, ...19176525, 11078583, 9029150, 23186163, 24966171, 15304344, 19920149, 12110590, 7737130, 21406692, 15192015, 20562914, 10518804, 9430721, 25545367, 7824938, 17671211, 20178980, 10085140, 19690332, 11896587, 24118792, 31072823, 7535770, 15105425, 19822663, 25041846, 21098032, 32993798, 21296815, 19647037, 24982422, 10777545, 24413065, 26225425, 11259436, 20140229, 20068231, 7737129
T73 Phosphorylation Q99986 (VRK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 20140229, 15105425
K77 Ubiquitination PhosphoSitePlus
S90 Phosphorylation P28482 (MAPK1) , P45984 (MAPK9) , Q16539 (MAPK14) , P45983 (MAPK8) , P53778 (MAPK12) PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21406692, 15304344, 33188182, ...11078583, 9029150, 10085140, 7737130
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
S112 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
S112 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332, 20068231
T116 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18847512, 20068231
S121 Phosphorylation P05771-2 (PRKCB) , P17252 (PRKCA) PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 9436983, 10475063, 19176525
S136 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
S136 Phosphorylation PhosphoSitePlus   UniProt 23186163
T226 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
S234 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
T236 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
S238 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
T253 Phosphorylation IEDB 35494241
T283 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
T283 Phosphorylation PhosphoSitePlus
T290 O-Glycosylation GlyGen 34019948, 32938750, 30059200, ...35254053, 35132862, 31492838, 29351928, 29237092
T290 Phosphorylation PhosphoSitePlus
T294 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
T305 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S310 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T320 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
S321 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
S321 Phosphorylation PhosphoSitePlus
T323 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
T325 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus   UniProt 24275569, 18220336
T332 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053, 29237092
T333 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus   UniProt 19176525
K357 Acetylation PhosphoSitePlus   UniProt 17590016
S367 Phosphorylation PhosphoSitePlus   UniProt 19176525
K374 Acetylation PhosphoSitePlus   UniProt 17590016
K409 Ubiquitination PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus   UniProt 24275569
S446 Phosphorylation PhosphoSitePlus   UniProt 24275569
T449 Phosphorylation PhosphoSitePlus
S490 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15916964, 25041846
S498 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15916964, 25041846
Site PTM Type PTM Enzyme Score Source PMID
T69 Phosphorylation P45984 (MAPK9) , Q16539 (MAPK14) HPRD 19413330, 18767875, 7535770, ...19651622, 18669648, 12110590, 20068231
T71 Phosphorylation Q16539 (MAPK14) , P45984 (MAPK9) HPRD 19413330, 18767875, 7535770, ...19651622, 18669648, 12110590, 20068231
T73 Phosphorylation HPRD 18669648
S90 Phosphorylation Q16539 (MAPK14) HPRD 19413330, 10085140, 11259586
S112 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
T116 Phosphorylation HPRD 18669648, 20068231
K357 Acetylation PR:000007102 (EP300) PRO 17590016
K374 Acetylation PR:000007102 (EP300) PRO 17590016


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046410 (hATF2/Phos:1) pT69,pT71 PRO
PR:000028565 (hATF2/iso:1/Ac:1) acK357,acK374 PR:000007102 (EP300) PRO 17590016


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 Y9 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T73 A73 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K105 T105 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S112 P112 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T116 A116 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S136 N136 Biomuta DOID:363 / uterine cancer [ icgc ]
T294 I294 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T305 S305 Biomuta DOID:4159 / skin cancer [ cosmic ]
S310 F310 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S321 F321 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S328 F328 Biomuta DOID:4159 / skin cancer [ cosmic ]
S438 L438 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S442 P442 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S442 L442 Biomuta DOID:4159 / skin cancer [ cosmic ]
S446 T446 Biomuta DOID:9256 / colorectal cancer [ cosmic ]