iPTMnet Report for P15311 (EZR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15311 / EZRI_HUMAN
Protein Name Ezrin
Gene Name Name: EZR
Synonyms:VIL2;
Organism Homo sapiens (Human)

PRO ID PR:P15311
DAG View
PRO Name ezrin (human)
Definition An ezrin that is encoded in the genome of human.
Short Label hEZR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15311 (EZR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
T10 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35008409, 30379171, 34725712, 34019948, 35083852, 22967762, 32119511, 36240223, 36796536
T11 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35008409, 30379171, 34725712, 34019948, 35083852, 22967762, 32119511, 36240223, 36796536
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus   UniProt 19608861
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S66 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P 12840026, 26405038, 28504189
K72 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation P00533 (EGFR) , P16591 (FER) , P12931 (SRC) , P06239 (LCK) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15647376, 25867068, 1382070, ...12560083, 26936397, 18046454
S149 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
R171 Methylation PhosphoSitePlus
K184 Acetylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Y191 Phosphorylation IntAct   PhosphoSitePlus 15647376
Y201 Phosphorylation PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K230 Sumoylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K233 Sumoylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
T235 Phosphorylation Q00535 (CDK5) HPRD   neXtProt   RLIMS-P   Signor 12769842, 16510591
K237 Ubiquitination PhosphoSitePlus
S243 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35008409, 30379171, 34725712, 34019948, 35083852, 22967762, 32119511, 36240223, 36796536
S243 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K253 Acetylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K254 Acetylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K258 Acetylation PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K262 Sumoylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K263 Acetylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
R273 Methylation PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
K306 Methylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K316 Acetylation PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y354 Phosphorylation P16591 (FER) , P00533 (EGFR) HPRD   IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10377409, 20348881, 15647376, ...25867068, 1382070
K357 Sumoylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
T358 O-Glycosylation GlyGen 16408927, 33214551, 28510447, ...35008409, 30379171, 34725712, 34019948, 35083852, 22967762, 32119511, 36240223, 36796536
T358 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus   UniProt 23186163
R393 Methylation PhosphoSitePlus
K412 Acetylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
R435 Methylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
Y478 Phosphorylation P12931 (SRC) , P16591 (FER) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18046454, 25867068, 15623525, ...22397367
S482 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S536 Phosphorylation HPRD   PhosphoSitePlus 18212344
S539 Phosphorylation HPRD   PhosphoSitePlus 19664994
T548 Phosphorylation PhosphoSitePlus
K564 Methylation PhosphoSitePlus
Y565 Phosphorylation PhosphoSitePlus
T567 Phosphorylation P17252 (PRKCA) , Q5S007 (LRRK2) , P41279 (MAP3K8) , P61586 (RHOA) , O94804 (STK10) , O95819 (MAP4K4) , P25098 (GRK2) , P31751 (AKT2) , Q13464 (ROCK1) , Q04759 (PRKCQ) , Q9P289 (STK26) , P41743 (PRKCI) , O75116 (ROCK2) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18078820, 21979959, 10893267, ...19804365, 26212029, 17447891, 24462708, 15843435, 9456324, 21878630, 21818323, 16873375, 31638145, 19234486, 23313818, 24599031, 19889841, 24581231, 19913059, 20711218, 19651779, 24346284, 19386264, 35625669, 25020230, 28962916, 26673134, 32647287, 30210460, 31879279, 14993232, 20585869, 21971708, 15647376, 14504278, 19255442, 22147261, 31775562, 18270268, 18025306, 25799996, 18480298, 11387207, 15531580, 26405038, 28085542, 30234483, 17628548, 20348881, 21363921, 35325754, 19648886, 27825102, 28493957, 10970850, 26563429, 35267019, 31409639, 15751968, 28430576
T576 Phosphorylation PhosphoSitePlus
K577 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation PRO 12840026, 16438931
Y146 Phosphorylation PRO 1382070, 15647376
Y191 Phosphorylation PRO 15647376
Y354 Phosphorylation PRO 1382070, 18852256
T567 Phosphorylation PRO 15647376, 18852256, 16144865, ...18025306


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047345 (hEZR/InitMet-/Phos:5) pT567 PRO
PR:000047346 (hEZR/InitMet-/Phos:1) pY146,pY354 PRO
PR:000036588 (hEZR/iso:1/Phos:1) pY146,pY354 PRO 1382070
PR:000036589 (hEZR/iso:1/Phos:2) pS66 PRO 12840026, 16438931
PR:000036590 (hEZR/iso:1/Phos:3) pY191 PRO 15647376
PR:000036591 (hEZR/iso:1/Phos:4) pY146,pY191,pT567 PRO 15647376
PR:000036592 (hEZR/iso:1/Phos:5) pT567 PRO 16144865, 18025306
PR:000036625 (hEZR/iso:1/Phos:6) pY354,pT567 PRO 18852256


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P15311 (EZR) Y146 P00533 (EGFR) unknown eFIP 26936397


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036589 (hEZR/iso:1/Phos:2) Interaction PR:000002696 (WWOX/iso:1/UnMod) PRO 16438931
PR:000036590 (hEZR/iso:1/Phos:3) Interaction PR:P00523-1 (chick-SRC/iso:1) PRO 15647376
PR:000036592 (hEZR/iso:1/Phos:5) Interaction PR:P43403 (hZAP70) PRO 18025306
PR:P25445-1 (hFAS/iso:1) Interaction PR:P15311 (hEZR) PRO 14739941
PR:Q9NZC7-1 (hWWOX/iso:1) Interaction PR:000036589 (hEZR/iso:1/Phos:2) PRO 16438931


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K60 M60 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R171 Q171 Biomuta DOID:1319 / brain cancer [ cosmic ]
K211 N211 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K237 N237 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S249 F249 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K253 R253 Biomuta DOID:1324 / lung cancer [ cosmic ]
R273 H273 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K357 T357 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S366 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R393 C393 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ]
T425 I425 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K427 N427 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R435 L435 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R435 W435 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T497 M497 Biomuta [ cosmic ]
T567 M567 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K577 N577 Biomuta DOID:263 / kidney cancer [ cosmic ]