iPTMnet Report for P14868 (DARS1)
Protein Information
| UniProt AC / UniProt ID | P14868 / SYDC_HUMAN |
| Protein Name | Aspartate--tRNA ligase, cytoplasmic |
| Gene Name | Name: DARS1 Synonyms:DARS;ORFNames:PIG40; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P14868 |
| PRO Name | aspartate--tRNA ligase, cytoplasmic (human) |
| Definition | An aspartate--tRNA ligase, cytoplasmic that is encoded in the genome of human. |
| Short Label | hDARS1 |
| Category | organism-gene |
P14868 (DARS1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y24 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K40 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R43 | Methylation | score1 | PhosphoSitePlus | |||
| T52 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K55 | Acetylation | score1 | PhosphoSitePlus | |||
| R63 | Methylation | score1 | PhosphoSitePlus | |||
| K74 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K74 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K99 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K103 | Acetylation | score1 | PhosphoSitePlus | |||
| K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K110 | Acetylation | score1 | PhosphoSitePlus | |||
| K110 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S112 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K126 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S146 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R188 | Methylation | score1 | PhosphoSitePlus | |||
| S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K213 | Acetylation | score1 | PhosphoSitePlus | |||
| T220 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S225 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y239 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K241 | Acetylation | score1 | PhosphoSitePlus | |||
| K241 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y245 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S249 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163 | ||
| Y253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K254 | Acetylation | score1 | PhosphoSitePlus | |||
| K330 | Acetylation | score1 | PhosphoSitePlus | |||
| K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C334 | Methylation | score1 | IEDB | 31844290 | ||
| K338 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T343 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S369 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T370 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K374 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K374 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K381 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K383 | Acetylation | score1 | IEDB | 34357683 | ||
| K383 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y384 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T386 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y389 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y394 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y402 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T403 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K411 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S427 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K451 | Acetylation | score1 | PhosphoSitePlus | |||
| K451 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K453 | Acetylation | score1 | PhosphoSitePlus | |||
| K453 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T500 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S146 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S225 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T236 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S238 | Phosphorylation | score0 | HPRD | 17322306 | ||
| S249 | Phosphorylation | score0 | HPRD | 19413330, 18767875, 19664994, ... | ||
| Y253 | Phosphorylation | score0 | HPRD | 19413330 | ||
| T323 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S10 | C10 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R43 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] | |
| R63 | P63 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| R63 | C63 | Biomuta | [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| K103 | T103 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R188 | W188 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K213 | I213 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S225 | L225 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y253 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| K254 | E254 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K330 | T330 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K338 | T338 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y394 | C394 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| T500 | I500 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
DAG View