iPTMnet Report for P14317 (HCLS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14317 / HCLS1_HUMAN
Protein Name Hematopoietic lineage cell-specific protein
Gene Name Name: HCLS1
Synonyms:HS1;
Organism Homo sapiens (Human)

PRO ID PR:P14317
DAG View
PRO Name hematopoietic lineage cell-specific protein (human)
Definition A hematopoietic lineage cell-specific protein that is encoded in the genome of human.
Short Label hHCLS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14317 (HCLS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
T16 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 10806407
T23 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 10806407
S32 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K41 Acetylation PhosphoSitePlus   UniProt 19608861
K41 Ubiquitination PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
K118 Ubiquitination PhosphoSitePlus
K123 Acetylation PhosphoSitePlus   UniProt 19608861
K123 Ubiquitination PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
T148 Phosphorylation IEDB 35494241
Y153 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
R155 Methylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K192 Acetylation PhosphoSitePlus   UniProt 19608861
K192 Ubiquitination PhosphoSitePlus
Y198 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12522270, 15144186
S208 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation P07948 (LYN) , P09769 (FGR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8611520, 10066823, 30220969, ...15795233
K223 Acetylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K241 Acetylation PhosphoSitePlus   UniProt 19608861
T272 Phosphorylation PhosphoSitePlus
S275 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19690332, 24275569, ...16094384
T308 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S311 O-Glycosylation GlyGen 27655845, 35132862, 29351928
S312 O-Glycosylation GlyGen 27655845, 35132862, 32938750, ...29351928
S314 O-Glycosylation GlyGen 27655845, 35132862, 29351928
T333 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation phospho.ELM   PhosphoSitePlus 8578591
Y378 Phosphorylation P07948 (LYN) , P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 30220969, 16782030, 28465529, ...8578591, 9104825
Y397 Phosphorylation P09769 (FGR) , P07948 (LYN) , P43405 (SYK) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 23325840, 16782030, 30220969, ...26110819, 9183008, 15795233, 8578591, 9104825
Y481 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation P68400 (CSNK2A1) HPRD 10806407
T23 Phosphorylation P68400 (CSNK2A1) HPRD 10806407
Y103 Phosphorylation HPRD 15570572
Y198 Phosphorylation HPRD 12522270, 15144186
Y222 Phosphorylation P09769 (FGR) , P07948 (LYN) HPRD 10066823
S275 Phosphorylation HPRD 16094384
Y378 Phosphorylation P07948 (LYN) , P43405 (SYK) HPRD 9104825
Y397 Phosphorylation P43405 (SYK) , P07948 (LYN) HPRD 9104825


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 Y13 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K41 N41 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K60 N60 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y103 H103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K118 E118 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R155 H155 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T181 M181 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K192 N192 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S232 F232 Biomuta [ cosmic ]
K241 T241 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S275 N275 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S275 R275 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T333 I333 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y360 C360 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y397 S397 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y481 F481 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]