iPTMnet Report for P13861 (PRKAR2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13861 / KAP2_HUMAN
Protein Name cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene Name Name: PRKAR2A
Synonyms:PKR2,PRKAR2;
Organism Homo sapiens (Human)

PRO ID PR:P13861
DAG View
PRO Name cAMP-dependent protein kinase type II-alpha regulatory subunit (human)
Definition A cAMP-dependent protein kinase type II-alpha regulatory subunit that is encoded in the genome of human.
Short Label hPRKAR2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13861 (PRKAR2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895, 25944712
S48 Phosphorylation PhosphoSitePlus   UniProt 20068231
T54 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...17287340, 20068231
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 24275569, ...23186163, 20068231
S78 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...17287340, 24275569, 18088087, 19690332, 20068231
S80 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 18669648, ...24275569, 23186163, 18088087, 19690332, 20068231
S92 Phosphorylation PhosphoSitePlus
S99 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18318008, ...18669648, 11263724, 19690332
C101 S-Nitrosylation dbSNO 26338901
T104 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
K315 Methylation PhosphoSitePlus
K318 Acetylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y352 Phosphorylation PhosphoSitePlus
C359 Methylation IEDB 31844290
S383 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus   UniProt 23186163
S396 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation HPRD 6293815, 20068231
T54 Phosphorylation HPRD 18669648, 17287340, 20068231
S58 Phosphorylation HPRD 18669648, 17287340, 20068231
S78 Phosphorylation HPRD 19413330, 18691976, 18088087, ...6293815, 18767875, 20230923, 20058876, 18452278, 19651622, 18669648, 20187088, 18707149, 20166139, 17287340, 19415658, 20068231
S80 Phosphorylation HPRD 19413330, 18691976, 18088087, ...20230923, 18767875, 20058876, 19007248, 18452278, 17322306, 18669648, 20187088, 19651622, 18707149, 20166139, 17287340, 19415658, 20068231
S99 Phosphorylation P13861 (PRKAR2A) HPRD 6293815, 20230923, 19664995, ...18452278, 18669648, 20166139, 20068231
T104 Phosphorylation HPRD 18669648, 17081983, 20068231
Y105 Phosphorylation HPRD 17081983
S350 Phosphorylation HPRD 20068231
Y352 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T290 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus


P13861 (PRKAR2A) as PTM Enzyme



Substrate Site Score Source PMID
P13861-1 (PRKAR2A) S99 HPRD 6293815, 20230923, 19664995, ...18452278, 18669648, 20166139, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S48 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S80 L80 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S92 R92 Biomuta DOID:4159 / skin cancer [ cosmic ]
C101 F101 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S196 Y196 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S254 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S268 L268 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K280 Q280 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C359 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y385 C385 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S396 N396 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]