iPTMnet Report for P13674 (P4HA1)
Protein Information
| UniProt AC / UniProt ID | P13674 / P4HA1_HUMAN |
| Protein Name | Prolyl 4-hydroxylase subunit alpha-1 precursor |
| Gene Name | Name: P4HA1 Synonyms:P4HA; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P13674 |
| PRO Name | prolyl 4-hydroxylase subunit alpha-1 (human) |
| Definition | A prolyl 4-hydroxylase subunit alpha-1 that is encoded in the genome of human. |
| Short Label | hP4HA1 |
| Category | organism-gene |
DAG ViewP13674 (P4HA1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T40 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S41 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K43 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y45 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K47 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K62 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N113 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 29741879, 19159218, ... | ||
| K132 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K150 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K230 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N259 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| Y282 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K288 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K299 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C310 | Methylation | score1 | IEDB | 31844290 | ||
| K327 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S345 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K353 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T364 | Phosphorylation | score1 | IEDB | 35494241 | ||
| S366 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T375 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| K382 | Acetylation | score1 | PhosphoSitePlus | |||
| K382 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S387 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K442 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C503 | Methylation | score1 | IEDB | 31844290 | ||
| K510 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K515 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K372 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K382 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S41 | F41 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S41 | Y41 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K62 | T62 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K72 | Q72 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| T375 | M375 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y378 | D378 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K382 | E382 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| C503 | F503 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| K510 | * | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| K515 | T515 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
