iPTMnet Report for P13645 (KRT10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13645 / K1C10_HUMAN
Protein Name Keratin, type I cytoskeletal 10
Gene Name Name: KRT10
Synonyms:KPP;
Organism Homo sapiens (Human)

PRO ID PR:P13645
DAG View
PRO Name keratin, type I cytoskeletal 10 (human)
Definition A keratin, type I cytoskeletal 10 that is encoded in the genome of human.
Short Label hKRT10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13645 (KRT10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 23186163
S16 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S38 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S42 O-Glycosylation GlyGen 25813380
S42 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S48 O-Glycosylation GlyGen 25813380
S49 O-Glycosylation GlyGen 25813380
S53 Phosphorylation PhosphoSitePlus   UniProt 23186163
S56 O-Glycosylation GlyGen 26853435, 33214551, 35083852, ...34019948, 29351928
S56 Phosphorylation PhosphoSitePlus   UniProt 23186163
S58 O-Glycosylation GlyGen 26853435, 33214551, 35083852, ...34019948, 29351928
S62 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y172 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
K284 Sumoylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S298 Phosphorylation HPRD 18691976
Q316 Methylation IEDB 29786170
Y325 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
T430 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 F13 Biomuta DOID:4159 / skin cancer [ cosmic ]
S38 N38 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S53 G53 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S56 Y56 Biomuta [ cosmic ]
S56 C56 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S62 F62 Biomuta DOID:4159 / skin cancer [ cosmic ]
K163 R163 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S188 * Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T277 I277 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y282 F282 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y325 H325 Biomuta DOID:1324 / lung cancer [ cosmic ]
S459 F459 Biomuta DOID:4159 / skin cancer [ cosmic ]
S535 C535 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S535 A535 Biomuta DOID:263 / kidney cancer [ cosmic ]
S546 G546 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
S546 R546 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S568 T568 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S571 F571 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S577 Y577 Biomuta DOID:363 / uterine cancer [ icgc ]
S578 T578 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S579 F579 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y584 C584 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]