iPTMnet Report for P13639 (EEF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13639 / EF2_HUMAN
Protein Name Elongation factor 2
Gene Name Name: EEF2
Synonyms:EF2;
Organism Homo sapiens (Human)

PRO ID PR:P13639
DAG View
PRO Name elongation factor 2 (human)
Definition An elongation factor 2 that is encoded in the genome of human.
Short Label hEEF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13639 (EEF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R10 Methylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
C41 Methylation IEDB 31844290
C41 S-Nitrosylation dbSNO 19483679, 26338901, 19101475, ...20140087, 22126794, 22178444, 2212679
K42 Acetylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S48 Phosphorylation HPRD   PhosphoSitePlus 19413330
R50 Methylation PhosphoSitePlus
T54 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 91085562, 2261989, ...20068231
T54 Phosphorylation O00418 (EEF2K) HPRD 91085562, 20068231
T57 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29435015, 23184662, 11500363, ...18188169, 21406692, 23186163, 18212344, 9133370, 8386634, 12194824, 12171600, 18767875, 19651622, 18614030, 2261989, 16083285, 17287340, 17081983, 18669648, 20166139, 20068231
T57 Phosphorylation O00418 (EEF2K) HPRD   neXtProt   Signor 17287340, 18212344, 12171600, ...9133370, 19651622, 18669648, 8386634, 20068231, 18767875, 20166139, 18614030, 11500363, 12194824, 18188169
T59 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 21406692, 23186163, ...18767875, 2261989, 19651622, 18669648, 8386634, 20068231
T59 Phosphorylation O00418 (EEF2K) HPRD   Signor 19413330, 2261989, 18767875, ...19651622, 18669648, 8386634, 20068231
C67 S-Nitrosylation dbSNO 19483679
S72 Phosphorylation PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
Y79 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
C136 Methylation IEDB 31844290
K152 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus   UniProt 19608861
K235 Ubiquitination PhosphoSitePlus
K239 Acetylation PhosphoSitePlus   UniProt 19608861
K239 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K258 Acetylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
R264 Methylation IEDB   PhosphoSitePlus 32357974
Y265 Phosphorylation PhosphoSitePlus   UniProt 24648518
K272 Acetylation PhosphoSitePlus   UniProt 19608861
K272 Methylation IEDB   PhosphoSitePlus 32357974
K272 Ubiquitination PhosphoSitePlus
F273 Methylation IEDB 32357974
S274 Phosphorylation PhosphoSitePlus
K275 Acetylation PhosphoSitePlus   UniProt 19608861
K275 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
C290 S-Nitrosylation dbSNO 19483679, 26338901, 25040305
K308 Acetylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K318 Acetylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
K322 Sumoylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
C369 S-Nitrosylation dbSNO 26338901, 22178444, 20140087
Y373 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15592455, 24648518
K386 Ubiquitination PhosphoSitePlus
K391 Acetylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S399 Phosphorylation HPRD   PhosphoSitePlus 20068231
K400 Ubiquitination PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
K407 Acetylation PhosphoSitePlus
K407 Methylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
R409 Methylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
R428 Methylation PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
T435 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 18847512, ...19664994, 17322306, 18669648, 20068231
T435 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K438 Acetylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K439 Acetylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
Y443 Phosphorylation HPRD   PhosphoSitePlus 20068231
K445 Acetylation PhosphoSitePlus   UniProt 19608861
K445 Methylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
C466 Methylation IEDB 31844290
K481 Ubiquitination PhosphoSitePlus
T487 O-Glycosylation GlyGen 33465208
R495 Methylation PhosphoSitePlus
K498 Acetylation PhosphoSitePlus
K498 Methylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
S500 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...18369606, 35138101, 30397120, 34725712, 26853435, 34019948, 25367160, 35008409, 35132862, 35083852, 20305658, 32119511, 33465208
S500 Phosphorylation PhosphoSitePlus   RLIMS-P 27956550
S502 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 20068231
K512 Ubiquitination PhosphoSitePlus
K519 Methylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K525 Methylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
R526 Methylation PhosphoSitePlus
K529 Sumoylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
C567 S-Nitrosylation dbSNO 19483679, 16648260, 22178444
K571 Ubiquitination PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
C591 Methylation IEDB 31844290
C591 S-Nitrosylation dbSNO 19483679
S593 Phosphorylation PhosphoSitePlus
K594 Methylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23184662, 23186163
S595 Phosphorylation P24941 (CDK2) PhosphoSitePlus 23184662
K598 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
S623 Phosphorylation HPRD   PhosphoSitePlus 20068231
K629 Ubiquitination PhosphoSitePlus
K638 Acetylation PhosphoSitePlus
K638 Methylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
C651 Methylation IEDB 31844290
C651 S-Nitrosylation dbSNO 20140087, 22178444
T657 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...18369606, 35138101, 30397120, 34725712, 26853435, 34019948, 25367160, 35008409, 35132862, 35083852, 20305658, 32119511, 33465208
K667 Ubiquitination PhosphoSitePlus
Y671 Phosphorylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
K688 Acetylation PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
C693 Methylation IEDB 31844290
R698 Methylation PhosphoSitePlus
R716 Methylation PhosphoSitePlus
T724 Phosphorylation HPRD   PhosphoSitePlus 20068231
R726 Methylation PhosphoSitePlus
C728 S-Nitrosylation dbSNO 19483679, 25040305
Y730 Phosphorylation PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
R739 Methylation PhosphoSitePlus
Y745 Phosphorylation PhosphoSitePlus
C751 Methylation IEDB 31844290
Y760 Phosphorylation PhosphoSitePlus
K766 Ubiquitination PhosphoSitePlus
R767 Methylation PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
S802 Phosphorylation PhosphoSitePlus
C812 Methylation IEDB 31844290
K842 Ubiquitination PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
K857 Acetylation PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 Y23 Biomuta DOID:1319 / brain cancer [ icgc ]
C41 Y41 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S48 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R50 W50 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R50 P50 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T54 S54 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T57 I57 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T73 I73 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K251 T251 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R264 S264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S274 C274 Biomuta DOID:4159 / skin cancer [ cosmic ]
S274 G274 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S279 R279 Biomuta DOID:3571 / liver cancer [ cosmic ]
K330 T330 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C369 * Biomuta DOID:1612 / breast cancer [ cosmic ]
C369 R369 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S399 F399 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R409 W409 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K445 R445 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K445 Q445 Biomuta DOID:10534 / stomach cancer [ icgc ]
K481 N481 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R495 L495 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R495 Q495 Biomuta DOID:263 / kidney cancer [ cosmic ]
K519 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R526 W526 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S530 P530 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T582 M582 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R698 W698 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
R716 H716 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R716 C716 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R739 C739 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K766 N766 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]