iPTMnet Report for P12277 (CKB)
Protein Information
UniProt AC / UniProt ID | P12277 / KCRB_HUMAN |
Protein Name | Creatine kinase B-type |
Gene Name | Name: CKB Synonyms:CKBB; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P12277 |
PRO Name | creatine kinase B-type (human) |
Definition | A creatine kinase B-type that is encoded in the genome of human. |
Short Label | hCKB |
Category | organism-gene |
P12277 (CKB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S4 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 19413330, 23186163, 20068231, ... | ||
S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
K11 | Ubiquitination | score1 | PhosphoSitePlus | |||
R13 | Methylation | score1 | PhosphoSitePlus | |||
S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
K32 | Ubiquitination | score1 | PhosphoSitePlus | |||
T35 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 23186163, 20058876, 19651622, ... | ||
Y39 | Phosphorylation | score1 | PhosphoSitePlus | |||
R43 | Methylation | score1 | PhosphoSitePlus | |||
K45 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y82 | Phosphorylation | score1 | PhosphoSitePlus | |||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
R96 | Methylation | score1 | PhosphoSitePlus | |||
K101 | Ubiquitination | score1 | PhosphoSitePlus | |||
K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
T108 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y125 | Phosphorylation | score1 | PhosphoSitePlus | |||
S128 | Phosphorylation | score1 | PhosphoSitePlus | |||
T133 | Phosphorylation | score1 | PhosphoSitePlus | |||
S136 | Phosphorylation | score1 | PhosphoSitePlus | |||
R138 | Methylation | score1 | PhosphoSitePlus | |||
K156 | Ubiquitination | score1 | PhosphoSitePlus | |||
S164 | Phosphorylation | score1 | PhosphoSitePlus | |||
R172 | Methylation | score1 | PhosphoSitePlus | |||
Y173 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y174 | Phosphorylation | score1 | PhosphoSitePlus | |||
S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
K196 | Ubiquitination | score1 | PhosphoSitePlus | |||
S199 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
R215 | Methylation | score1 | PhosphoSitePlus | |||
K223 | Sumoylation | score1 | PhosphoSitePlus | |||
K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
K242 | Ubiquitination | score1 | PhosphoSitePlus | |||
K247 | Ubiquitination | score1 | PhosphoSitePlus | |||
C254 | S-Nitrosylation | score0 | dbSNO | 19483679, 25040305 | ||
T255 | Phosphorylation | score1 | PhosphoSitePlus | |||
K265 | Ubiquitination | score1 | PhosphoSitePlus | |||
K267 | Acetylation | score1 | PhosphoSitePlus | |||
Y269 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y279 | Phosphorylation | score1 | PhosphoSitePlus | |||
S285 | Phosphorylation | score1 | PhosphoSitePlus | |||
K298 | Ubiquitination | score1 | PhosphoSitePlus | |||
K304 | Ubiquitination | score1 | PhosphoSitePlus | |||
K307 | Sumoylation | score1 | PhosphoSitePlus | |||
K307 | Ubiquitination | score1 | PhosphoSitePlus | |||
S309 | Phosphorylation | score1 | PhosphoSitePlus | |||
K313 | Acetylation | score1 | PhosphoSitePlus | |||
K313 | Ubiquitination | score1 | PhosphoSitePlus | |||
R320 | Methylation | score1 | PhosphoSitePlus | |||
T322 | Phosphorylation | score1 | PhosphoSitePlus | |||
T327 | Phosphorylation | score1 | PhosphoSitePlus | |||
S337 | Phosphorylation | score1 | PhosphoSitePlus | |||
K381 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R13 | H13 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] | |
R43 | H43 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
T108 | I108 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T133 | M133 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
Y173 | H173 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
S178 | C178 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K247 | N247 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K265 | R265 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
R320 | Q320 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T327 | R327 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |