iPTMnet Report for P11831 (SRF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11831 / SRF_HUMAN
Protein Name Serum response factor
Gene Name Name: SRF
Organism Homo sapiens (Human)

PRO ID PR:P11831
DAG View
PRO Name serum response factor (human)
Definition A serum response factor that is encoded in the genome of human.
Short Label hSRF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11831 (SRF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
R14 Methylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
R24 Methylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
T36 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
R37 Methylation PhosphoSitePlus
T71 Phosphorylation HPRD   IEDB 32387766, 17081983
Y76 Phosphorylation HPRD 17081983
S77 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 1547771, 17081983, ...2046671
S79 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 1547771, 2046671, ...17081983
S83 Phosphorylation P68400 (CSNK2A1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 1740119, 18669648, 1547771, ...2046671
S85 Phosphorylation P49137 (MAPKAPK2) , P68400 (CSNK2A1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 11859076, 10318869, ...1547771, 18669648, 2046671
S101 Phosphorylation PhosphoSitePlus
S103 Phosphorylation P49137 (MAPKAPK2) , O75582 (RPS6KA5) , Q15418 (RPS6KA1) , Q9UQM7 (CAMK2A) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11859076, 10318869, 10753652, ...1547771, 12171911, 20089855, 8413226, 7929249, 21074607, 32933333
K147 Sumoylation PhosphoSitePlus
K154 Methylation PhosphoSitePlus
T159 Phosphorylation P17612 (PRKACA) , Q13976 (PRKG1) , Q09013 (DMPK) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P 19778940, 12809504
T160 Phosphorylation Q9UQM7 (CAMK2A) , Q05655 (PRKCD) HPRD   neXtProt   RLIMS-P 15282327, 10753652
S162 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 16537394
K165 Methylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S224 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 19664994, ...18669648, 34381779, 24275569, 20068231
S228 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S251 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 8375385
S277 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 29351928, ...34019948, 1687959, 12684542, 1512232
T288 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S307 O-Glycosylation GlyGen   UniProt 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S309 O-Glycosylation GlyGen   UniProt 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S311 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S313 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S316 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 29351928, ...34019948, 1687959, 12684542, 1512232
S370 Phosphorylation PhosphoSitePlus
S383 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S384 O-Glycosylation GlyGen 1512232
S385 O-Glycosylation GlyGen 1512232
T401 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S435 Phosphorylation P78527 (PRKDC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 8407951
S446 Phosphorylation P78527 (PRKDC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 8407951
T460 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S462 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S463 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
T465 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232
S471 O-Glycosylation GlyGen 23301498, 35138101, 29351928, ...34019948, 12684542, 1512232


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P11831 (SRF) S103 P11831 (SRF) increased_association eFIP 11859076


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T36 A36 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S221 L221 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S313 G313 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S316 G316 Biomuta DOID:3571 / liver cancer [ cosmic ]
S385 T385 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S435 Y435 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S462 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S463 F463 Biomuta DOID:4159 / skin cancer [ cosmic ]