iPTMnet Report for P11717 (IGF2R)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P11717 / MPRI_HUMAN
Protein Name Cation-independent mannose-6-phosphate receptor precursor
Gene Name Name: IGF2R
Synonyms:MPRI;
Organism Homo sapiens (Human)

PRO ID PR:P11717
DAG View
PRO Name cation-independent mannose-6-phosphate receptor (human)
Definition A cation-independent mannose-6-phosphate receptor that is encoded in the genome of human.
Short Label hIGF2R
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P11717 (IGF2R) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus
N67 N-Glycosylation GlyGen 29391424
K89 Ubiquitination PhosphoSitePlus
S99 O-Glycosylation GlyGen 33214551, 34725712, 35254053, ...34019948, 34931806, 32119511, 35289036
S103 O-Glycosylation GlyGen 33214551, 34725712, 35254053, ...34019948, 34931806, 32119511, 35289036
T105 O-Glycosylation GlyGen 33214551, 34725712, 35254053, ...34019948, 34931806, 32119511, 35289036
N112 N-Glycosylation GlyGen   UniProt 23090970, 12754519, 29671580, ...29391424, 24190977
K170 Ubiquitination PhosphoSitePlus
C174 Methylation IEDB 34433824
K183 Ubiquitination PhosphoSitePlus
N210 N-Glycosylation GlyGen 29391424
S223 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
N400 N-Glycosylation GlyGen 29741879, 29391424, 24190977
S428 O-Glycosylation GlyGen 33214551, 34725712, 35254053, ...34019948, 34931806, 32119511, 35289036
N431 N-Glycosylation GlyGen 24190977
N435 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N440 N-Glycosylation GlyGen 24190977
T507 Phosphorylation PhosphoSitePlus
N517 N-Glycosylation GlyGen 29391424
N543 N-Glycosylation GlyGen 23090970, 24190977
N581 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...24190977
N626 N-Glycosylation GlyGen   UniProt 29741879, 19159218
K687 Ubiquitination PhosphoSitePlus
Y700 Phosphorylation PhosphoSitePlus
Y701 Phosphorylation PhosphoSitePlus
Y709 Phosphorylation PhosphoSitePlus
R710 Methylation PhosphoSitePlus
N747 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...19159218, 24190977
T770 O-Glycosylation GlyGen 30459171
K808 Ubiquitination PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
N871 N-Glycosylation GlyGen 29741879
N951 N-Glycosylation GlyGen 24190977
N957 N-Glycosylation GlyGen 24190977
K1052 Ubiquitination PhosphoSitePlus
K1104 Ubiquitination PhosphoSitePlus
T1107 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1111 Phosphorylation HPRD 20068231
C1217 Methylation IEDB 31844290
K1230 Ubiquitination PhosphoSitePlus
N1246 N-Glycosylation GlyGen   UniProt 29741879, 12754519, 24190977
K1264 Ubiquitination PhosphoSitePlus
T1272 Phosphorylation PhosphoSitePlus
K1277 Sumoylation PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
S1281 Phosphorylation PhosphoSitePlus
K1293 Ubiquitination PhosphoSitePlus
K1301 Ubiquitination PhosphoSitePlus
N1312 N-Glycosylation GlyGen 23090970, 29741879, 24190977
T1346 Phosphorylation PhosphoSitePlus
S1347 Phosphorylation PhosphoSitePlus
Y1592 Phosphorylation PhosphoSitePlus
C1598 Methylation IEDB 31844290
K1601 Ubiquitination PhosphoSitePlus
N1656 N-Glycosylation GlyGen 29741879, 29391424
S1658 O-Glycosylation GlyGen 33214551, 34725712, 35254053, ...34019948, 34931806, 32119511, 35289036
S1664 O-Glycosylation GlyGen 33214551, 34725712, 35254053, ...34019948, 34931806, 32119511, 35289036
N1757 N-Glycosylation GlyGen 29741879, 29391424, 24190977
S1771 Phosphorylation PhosphoSitePlus
T1774 Phosphorylation PhosphoSitePlus
K1776 Ubiquitination PhosphoSitePlus
T1828 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1831 Phosphorylation HPRD   PhosphoSitePlus 20068231
C1839 Methylation IEDB 31844290
K1862 Ubiquitination PhosphoSitePlus
S1865 Phosphorylation PhosphoSitePlus
S1871 Phosphorylation PhosphoSitePlus
K1873 Ubiquitination PhosphoSitePlus
C1975 Methylation IEDB 31844290
T2002 Phosphorylation PhosphoSitePlus
Y2024 Phosphorylation PhosphoSitePlus
Y2025 Phosphorylation PhosphoSitePlus
N2085 N-Glycosylation GlyGen 24190977
T2087 Phosphorylation HPRD 20068231
C2096 Methylation IEDB 31844290
N2136 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...24190977
N2141 N-Glycosylation GlyGen 24190977
Y2154 Phosphorylation PhosphoSitePlus
S2189 Phosphorylation PhosphoSitePlus
T2209 Phosphorylation PhosphoSitePlus
S2210 Phosphorylation PhosphoSitePlus
K2338 Ubiquitination PhosphoSitePlus
S2346 Phosphorylation PhosphoSitePlus
S2347 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 8318012
N2348 N-Glycosylation GlyGen 29391424
S2350 Phosphorylation PhosphoSitePlus
Y2351 Phosphorylation PhosphoSitePlus
K2352 Acetylation PhosphoSitePlus   UniProt 19608861
K2352 Ubiquitination PhosphoSitePlus
Y2353 Phosphorylation PhosphoSitePlus
S2354 Phosphorylation PhosphoSitePlus
T2362 Phosphorylation PhosphoSitePlus
K2383 Ubiquitination PhosphoSitePlus
K2394 Ubiquitination PhosphoSitePlus
S2395 Phosphorylation PhosphoSitePlus
S2400 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S2401 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18578522
S2409 Phosphorylation P68400 (CSNK2A1) HPRD   IEDB   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 18691976, 18578522, ...23186163, 17081983, 20230923, 8318012, 19664994, 21406692, 18452278, 19651622, 34433824, 18669648, 19690332, 24275569, 18707149, 20166139, 19415658, 20068231
T2415 Phosphorylation PhosphoSitePlus
K2420 Ubiquitination PhosphoSitePlus
R2425 Methylation PhosphoSitePlus
K2470 Ubiquitination PhosphoSitePlus
K2476 Ubiquitination PhosphoSitePlus
S2479 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 19651622, ...18669648, 24275569, 19690332, 20068231
S2484 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18578522, 17693683, 18318008, ...18691976, 21406692, 23186163, 20230923, 18452278, 19367720, 24275569, 17487921, 19690332, 8318012, 18220336, 18767875, 19651622, 19369195, 17081983, 19664994, 19664995, 17322306, 18669648, 20166139, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
N112 N-Glycosylation PRO 29671580
N1312 N-Glycosylation PRO 29741879


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S99 C99 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K170 Q170 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K183 Q183 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N210 I210 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N210 Y210 Biomuta DOID:4159 / skin cancer [ cosmic ]
S223 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T296 I296 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
N626 K626 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R710 G710 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1052 E1052 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1107 M1107 Biomuta DOID:1324 / lung cancer [ cosmic ]
C1217 F1217 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1277 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1277 N1277 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C1598 W1598 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T1774 M1774 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2347 C2347 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N2348 S2348 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S2350 F2350 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y2351 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K2394 M2394 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2394 T2394 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2395 A2395 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K2420 Q2420 Biomuta DOID:184 / bone cancer [ cosmic ]
K2470 R2470 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S2479 F2479 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]