iPTMnet Report for P11509 (CYP2A6)
Protein Information
UniProt AC / UniProt ID | P11509 / CP2A6_HUMAN |
Protein Name | Cytochrome P450 2A6 |
Gene Name | Name: CYP2A6 Synonyms:CYP2A3; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P11509 |
PRO Name | cytochrome P450 2A6 (human) |
Definition | A cytochrome P450 2A that is a translation product of the CYP2A6 gene in human. |
Short Label | hCYP2A6 |
Category | organism-gene |
P11509 (CYP2A6) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
T16 | Phosphorylation | score1 | PhosphoSitePlus | |||
S22 | Phosphorylation | score1 | PhosphoSitePlus | |||
S131 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20166139 | ||
R148 | Methylation | score1 | PhosphoSitePlus | |||
R161 | Methylation | score1 | PhosphoSitePlus | |||
T163 | Phosphorylation | score1 | PhosphoSitePlus | |||
S175 | Phosphorylation | score1 | PhosphoSitePlus | |||
T177 | Phosphorylation | score1 | PhosphoSitePlus | |||
S183 | Phosphorylation | score1 | PhosphoSitePlus | |||
S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
T295 | Phosphorylation | score1 | PhosphoSitePlus | |||
S403 | Phosphorylation | score1 | PhosphoSitePlus | |||
K436 | Acetylation | score1 | PhosphoSitePlus | |||
T488 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R148 | C148 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R148 | H148 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] | |
R161 | W161 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T295 | M295 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |