iPTMnet Report for P10916 (MYL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10916 / MLRV_HUMAN
Protein Name Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Gene Name Name: MYL2
Synonyms:MLC2;
Organism Homo sapiens (Human)

PRO ID PR:P10916
DAG View
PRO Name myosin regulatory light chain 2, ventricular/cardiac muscle isoform (human)
Definition A myosin regulatory light chain 2, ventricular/cardiac muscle isoform that is encoded in the genome of human.
Short Label hMYL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10916 (MYL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation Q15746 (MYLK) PhosphoSitePlus   RLIMS-P   UniProt 22120626, 25412762, 20038585, ...20445002
S19 Phosphorylation Q5VT25 (CDC42BPA) HPRD   PhosphoSitePlus   RLIMS-P 9418861, 18648664, 33156861, ...28013338, 27169750, 17043135
T80 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus   RLIMS-P 25412762
T124 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K165 Acetylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10916 (MYL2) S15 O75116 (ROCK2) unknown eFIP 25412762


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K111 T111 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K111 N111 Biomuta DOID:1612 / breast cancer [ icgc ]
T124 I124 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K165 R165 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]