iPTMnet Report for P10909 (CLU)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10909 / CLUS_HUMAN
Protein Name Clusterin precursor
Gene Name Name: CLU
Synonyms:APOJ;ORFNames:AAG4;
Organism Homo sapiens (Human)

PRO ID PR:P10909
DAG View
PRO Name clusterin (human)
Definition A clusterin that is encoded in the genome of human.
Short Label hCLU
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10909 (CLU) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K54 Ubiquitination PhosphoSitePlus
K57 Sumoylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
N86 N-Glycosylation GlyGen   UniProt 16335952, 1551440, 30237853, ...19159218, 26791533, 9336835, 32125861, 19139490, 29741879
T88 Phosphorylation PhosphoSitePlus
N103 N-Glycosylation GlyGen   UniProt 16335952, 24530628, 1551440, ...32125861, 19159218, 29391424, 2721499, 9336835, 29741879, 29671580
K123 Acetylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus   UniProt 24275569
N145 N-Glycosylation GlyGen   UniProt 16335952, 1551440, 19159218, ...26791533, 9336835, 2721499, 29391424, 29741879
N155 N-Glycosylation GlyGen 23090970, 24190977
S185 Phosphorylation PhosphoSitePlus
S210 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K222 Ubiquitination PhosphoSitePlus
N239 N-Glycosylation GlyGen 24190977
N291 N-Glycosylation GlyGen   UniProt 16335952, 1551440, 32125861, ...29391424, 2721499, 9336835, 18780401, 29741879, 29671580
S310 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
N354 N-Glycosylation GlyGen   UniProt 16335952, 1551440, 29427759, ...19159218, 26791533, 14760718, 9336835, 32125861, 29391424, 29741879, 12754519
N374 N-Glycosylation GlyGen   UniProt 16335952, 24530628, 1551440, ...25855029, 19159218, 24190977, 14760718, 26791533, 29391424, 32125861, 16263699, 19139490, 19838169, 24279413, 9336835, 16740002, 18780401, 29741879, 29671580, 30237853
T376 O-Glycosylation GlyGen 34846842, 34725712, 35254053
T387 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus   RLIMS-P 22906254
S394 Phosphorylation PhosphoSitePlus   RLIMS-P 22906254
S396 O-Glycosylation GlyGen 30459171
S396 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22906254, 24275569
S412 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N86 N-Glycosylation PRO 29741879, 26791533
N103 N-Glycosylation PRO 29741879, 29671580
N145 N-Glycosylation PRO 26791533
N291 N-Glycosylation PRO 29671580
N354 N-Glycosylation PRO 26791533
N374 N-Glycosylation PRO 24279413, 19838169, 26791533, ...29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 R68 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K123 T123 Biomuta DOID:10283 / prostate cancer [ cosmic ]
N374 K374 Biomuta DOID:263 / kidney cancer [ cosmic ]
S396 L396 Biomuta DOID:1324 / lung cancer [ cosmic ]
S412 F412 Biomuta DOID:4159 / skin cancer [ cosmic ]